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Cellosaurus MOLT-17 (CVCL_2125)

[Text version]
Cell line name MOLT-17
Synonyms Molt-17; MOLT 17; MOLT17
Accession CVCL_2125
Resource Identification Initiative To cite this cell line use: MOLT-17 (RRID:CVCL_2125)
Comments Problematic cell line: Partially contaminated. The RCB/Riken RCB1982 stock was contaminated and was replaced by RCB4561 which originates from DSMZ ACC-36. On the basis of STR profile, the version at TKG (TKG 0385) seems to be identical or closely related to the RCB1962 contaminated stock.
Population: African American.
Doubling time: ~50 hours (DSMZ=ACC-36).
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1424 ! MOLT-16
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
STR profile Source(s): DSMZ; RCB; TKG

CSF1PO9,10,12 (RCB_RCB1982)
10,12 (TKG)
11,12 (DSMZ)
D5S81811,12 (DSMZ)
12 (TKG)
12,13 (RCB_RCB1982)
D7S82011 (TKG)
11,12,13 (RCB_RCB1982)
12 (DSMZ)
D13S31710,11,12 (RCB_RCB1982)
10,12 (TKG)
12 (DSMZ)
D16S5399,10 (DSMZ)
9,14,15 (RCB_RCB1982)
9,15 (TKG)
Penta D6,10
Penta E16
TH019 (RCB_RCB1982; TKG)
9,9.3 (DSMZ)
8,11 (DSMZ)
vWA16 (DSMZ)
17,18,19 (RCB_RCB1982)
18,19 (TKG)

Run an STR similarity search on this cell line
Web pages https://cell.brc.riken.jp/en/announcement/molt-17

PubMed=2961573; DOI=10.1002/eji.1830171208
Tighe L., Forster A., Clark D.M., Boylston A.W., Lavenir I., Rabbitts T.H.
Unusual forms of T cell gamma mRNA in a human T cell leukemia cell line: implications for gamma gene expression.
Eur. J. Immunol. 17:1729-1736(1987)

PubMed=2784121; DOI=10.1002/hon.2900070203
Drexler H.G., Minowada J.
Morphological, immunophenotypical and isoenzymatic profiles of human leukemia cells and derived T-cell lines.
Hematol. Oncol. 7:115-125(1989)

Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Borgonovo-Brandter L., Heyman M., Rasool O., Liu Y., Grander D., Einhorn S.
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

Cell line collections (Providers) DSMZ; ACC-36
NCBI_Iran; C516
RCB; RCB1982 - Discontinued
RCB; RCB4561
TKG; TKG 0385
Cell line databases/resources CLO; CLO_0051012
CLDB; cl3517
Cell_Model_Passport; SIDM00430
DSMZCellDive; ACC-36
Anatomy/cell type resources BTO; BTO:0004174
Biological sample resources BioSample; SAMN03472051
Encyclopedic resources Wikidata; Q54906348
Gene expression databases GEO; GSM5137762
Polymorphism and mutation databases Cosmic; 933539
Cosmic; 1118461
Cosmic; 2602928
Proteomic databases PRIDE; PXD023662
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number24