Cellosaurus cell line JURL-MK2 (CVCL

Cellosaurus JURL-MK2 (CVCL_2087)

[Text version]

Cell line name

JURL-MK2

Synonyms

JURLMK2

Accession

CVCL_2087

Resource Identification Initiative

To cite this cell line use: JURL-MK2 (RRID:CVCL_2087)

Comments

Population: Caucasian.
Doubling time: 72 hours (PubMed=9305612); ~72 hours (DSMZ=ACC-533).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=9305612; PubMed=10071072; PubMed=10576511).

Disease

Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_2086 ! JURL-MK1

Sex of cell

Male

Age at sampling

73Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-533

Markers:

Amelogenin	X,Y
CSF1PO	12
D2S1338	17,23
D3S1358	15,17
D5S818	12
D7S820	10,13
D8S1179	12,14
D13S317	11
D16S539	11,12
D18S51	13
D19S433	12,14
D21S11	27,29
FGA	21,23
Penta D	11,12
Penta E	14,16
TH01	8
TPOX	8,11
vWA	16,18

Publications

PubMed=9305612; DOI=10.1038/sj.leu.2400760
Di Noto R., Luciano L., Lo Pardo C., Ferrara F., Frigeri F., Mercuro O., Lombardi M.L., Pane F., Vacca C., Manzo C., Salvatore F., Rotoli B., Del Vecchio L.
JURL-MK1 (c-kit(high)/CD30-/CD40-) and JURL-MK2 (c-kit(low)/CD30+/CD40+) cell lines: 'two-sided' model for investigating leukemic megakaryocytopoiesis.
Leukemia 11:1554-1564(1997)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-533

Cell line databases/resources

CLO; CLO_0009839
Cell_Model_Passport; SIDM01014
CGH-DB; 9219-4
DSMZCellDive; ACC-533
LINCS_LDP; LCL-1102

Anatomy/cell type resources

BTO; BTO_0005910

Biological sample resources

BioSample; SAMN03473527

Encyclopedic resources

Wikidata; Q54899165

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number