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Cellosaurus JOSK-M (CVCL_2083)

[Text version]
Cell line name JOSK-M
Accession CVCL_2083
Resource Identification Initiative To cite this cell line use: JOSK-M (RRID:CVCL_2083)
Comments Problematic cell line: Contaminated. Shown to be a U-937 derivative (PubMed=10508494; PubMed=12592342; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00137.
Population: Caucasian.
Doubling time: ~30-40 hours (DSMZ=ACC-30).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-30

Markers:
AmelogeninX
CSF1PO12
D2S133817,20
D3S135816
D5S81813
D7S8209,11
D8S117911,16
D13S31710,12
D16S53912
D18S5113,14
D19S43314,16
D21S1127,29
FGA22,25
Penta D12,13
Penta E11,13
TH016,9.3
TPOX8,11
vWA14,15

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=3486043
Ohta M., Furukawa Y., Ide C., Akiyama N., Utakoji T., Miura Y., Saito M.
Establishment and characterization of four human monocytoid leukemia cell lines (JOSK-I, -S, -M and -K) with capabilities of monocyte-macrophage lineage differentiation and constitutive production of interleukin 1.
Cancer Res. 46:3067-3074(1986)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) DSMZ; ACC-30 - Discontinued
Cell line databases/resources CLO; CLO_0007035
CLDB; cl2952
cancercelllines; CVCL_2083
DSMZCellDive; ACC-30
Biological sample resources BioSample; SAMN03151982
BioSample; SAMN03473345
Encyclopedic resources Wikidata; Q54899047
Polymorphism and mutation databases Cosmic; 787439
Cosmic; 999773
IARC_TP53; 961
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number29