Cell line name |
JOSK-M |
Accession |
CVCL_2083 |
Resource Identification Initiative |
To cite this cell line use: JOSK-M (RRID:CVCL_2083) |
Comments |
Problematic cell line: Contaminated. Shown to be a U-937 derivative (PubMed=10508494; PubMed=12592342; PubMed=20143388). Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00137. Population: Caucasian. Doubling time: ~30-40 hours (DSMZ=ACC-30). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0007 (U-937) |
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
STR profile |
Source(s): DSMZ=ACC-30
Markers:Amelogenin | X |
CSF1PO | 12 |
D2S1338 | 17,20 |
D3S1358 | 16 |
D5S818 | 13 |
D7S820 | 9,11 |
D8S1179 | 11,16 |
D13S317 | 10,12 |
D16S539 | 12 |
D18S51 | 13,14 |
D19S433 | 14,16 |
D21S11 | 27,29 |
FGA | 22,25 |
Penta D | 12,13 |
Penta E | 11,13 |
TH01 | 6,9.3 |
TPOX | 8,11 |
vWA | 14,15 |
Run an STR similarity search on this cell line |
Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx |
Publications | PubMed=3486043 Ohta M., Furukawa Y., Ide C., Akiyama N., Utakoji T., Miura Y., Saito M. Establishment and characterization of four human monocytoid leukemia cell lines (JOSK-I, -S, -M and -K) with capabilities of monocyte-macrophage lineage differentiation and constitutive production of interleukin 1. Cancer Res. 46:3067-3074(1986) PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2 MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G. Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int. J. Cancer 83:555-563(1999) PubMed=12592342; DOI=10.1038/sj.leu.2402799 Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F. False leukemia-lymphoma cell lines: an update on over 500 cell lines. Leukemia 17:416-426(2003) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010) |
Cross-references |
Cell line collections (Providers) |
DSMZ; ACC-30 - Discontinued
|
Cell line databases/resources |
CLO; CLO_0007035
CLDB; cl2952
cancercelllines; CVCL_2083
DSMZCellDive; ACC-30
|
Biological sample resources |
BioSample; SAMN03151982
BioSample; SAMN03473345
|
Encyclopedic resources |
Wikidata; Q54899047
|
Polymorphism and mutation databases |
Cosmic; 787439
Cosmic; 999773
IARC_TP53; 961
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 02-May-2024 |
Version number | 28 |
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