Cell line name |
JOSK-I |
Accession |
CVCL_2082 |
Resource Identification Initiative |
To cite this cell line use: JOSK-I (RRID:CVCL_2082) |
Comments |
Problematic cell line: Contaminated. Shown to be a U-937 derivative (PubMed=10508494; PubMed=12592342; PubMed=20143388). Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00135. Population: Caucasian. Doubling time: ~28-35 hours (DSMZ=ACC-155). Misspelling: JOSK-1; Cosmic=947371. Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0007 (U-937) |
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
STR profile |
Source(s): DSMZ=ACC-155
Markers:Amelogenin | X |
CSF1PO | 12 |
D2S1338 | 17,20 |
D3S1358 | 16 |
D5S818 | 12 |
D7S820 | 9,11 |
D8S1179 | 12,13 |
D13S317 | 10,12 |
D16S539 | 12 |
D18S51 | 12,13 |
D19S433 | 14,16 |
D21S11 | 27,29 |
FGA | 22,25 |
Penta D | 12,13 |
Penta E | 13 |
TH01 | 6,9.3 |
TPOX | 8,11 |
vWA | 14,15 |
Run an STR similarity search on this cell line |
Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx |
Publications | PubMed=3486043 Ohta M., Furukawa Y., Ide C., Akiyama N., Utakoji T., Miura Y., Saito M. Establishment and characterization of four human monocytoid leukemia cell lines (JOSK-I, -S, -M and -K) with capabilities of monocyte-macrophage lineage differentiation and constitutive production of interleukin 1. Cancer Res. 46:3067-3074(1986) PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588 Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H. Frameshift mutations of the hMSH6 gene in human leukemia cell lines. Jpn. J. Cancer Res. 89:33-39(1998) PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2 MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G. Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int. J. Cancer 83:555-563(1999) PubMed=12592342; DOI=10.1038/sj.leu.2402799 Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F. False leukemia-lymphoma cell lines: an update on over 500 cell lines. Leukemia 17:416-426(2003) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010) |
Cross-references |
Cell line collections (Providers) |
DSMZ; ACC-155 - Discontinued
|
Cell line databases/resources |
CLO; CLO_0007034
CLDB; cl2951
cancercelllines; CVCL_2082
DSMZCellDive; ACC-155
|
Biological sample resources |
BioSample; SAMN03151980
|
Encyclopedic resources |
Wikidata; Q54899045
|
Polymorphism and mutation databases |
Cosmic; 787438
Cosmic; 919120
Cosmic; 947371
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 02-May-2024 |
Version number | 28 |
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