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Cellosaurus DM-3 (CVCL_2019)

[Text version]
Cell line name DM-3
Synonyms DM3
Accession CVCL_2019
Resource Identification Initiative To cite this cell line use: DM-3 (RRID:CVCL_2019)
Comments Problematic cell line: May be misclassified. While still annotated as a pleural sarcomatoid mesothelioma cell line, a variety of omics methods are classifying this cell line as a fibroblast (DOI=10.1101/166199; DepMap).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 54 hours (PubMed=23840376); ~50-60 hours (DSMZ=ACC-595).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Sequence variations
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg496Leu (c.1487G>T); Zygosity=Homozygous (DepMap).
HLA typing Source: PubMed=26589293
Class I
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North0.58
East Asian, South0.68
South Asian2.16
European, North58.64
European, South37.94
Disease Pleural sarcomatoid mesothelioma (NCIt: C45663)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Penta D11,12
Penta E7,12

Run an STR similarity search on this cell line

PubMed=15372243; DOI=10.1007/s00418-004-0701-1
Philippeaux M.-M., Pache J.-C., Dahoun S., Barnet M., Robert J.-H., Mauel J., Spiliopoulos A.
Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.
Histochem. Cell Biol. 122:249-260(2004)

PubMed=23840376; DOI=10.1371/journal.pone.0065903
Szulkin A., Nilsonne G., Mundt F., Wasik A.M., Souri P., Hjerpe A., Dobra K.
Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.
PLoS ONE 8:E65903-E65903(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=33567673; DOI=10.3390/cancers13040685
Keller M., Reis K., Hjerpe A., Dobra K., Aspenstrom P.
Cytoskeletal organization correlates to motility and invasiveness of malignant mesothelioma cells.
Cancers (Basel) 13:685.1-685.20(2021)

Cell line collections (Providers) DSMZ; ACC-595
Cell line databases/resources cancercelllines; CVCL_2019
Cell_Model_Passport; SIDM01505
DepMap; ACH-000742
DSMZCellDive; ACC-595
Biological sample resources BioSample; SAMN03473059
BioSample; SAMN10988453
Chemistry resources PharmacoDB; DM3_295_2019
Encyclopedic resources Wikidata; Q54831188
Gene expression databases ArrayExpress; E-MTAB-2770
Polymorphism and mutation databases IARC_TP53; 30031
LiGeA; CCLE_782
Progenetix; CVCL_2019
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number26