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Cellosaurus COV434 (CVCL_2010)

[Text version]
Cell line name COV434
Synonyms COV-434; COV 434
Accession CVCL_2010
Resource Identification Initiative To cite this cell line use: COV434 (RRID:CVCL_2010)
Comments Problematic cell line: Misclassified. Originally thought to be an ovarian granulosa cell tumor but seems to be a small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) (PubMed=33328126).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Characteristics: Because it conserved a number of properties of normal human granulosa cells, it is used in the investigation of such cell type.
Doubling time: 24 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Sequence variations
  • Mutation; HGNC; 11100; SMARCA4; Simple; c.3952-1G>C; ClinVar=VCV000635379; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=33328126; DepMap=ACH-000123).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:05,31:01
HLA-BB*44:02,50:01
HLA-CC*06:02,15:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.5
Native American0.68
East Asian, North0.76
East Asian, South0
South Asian0
European, North60.55
European, South36.51
Disease Ovarian small cell carcinoma, hypercalcemic type (NCIt: C40439)
Small cell carcinoma of the ovary (ORDO: Orphanet_370396)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): ECACC=07071909; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,19
D5S81810,11
D7S8208
D8S117913,14
D13S3178,12
D16S5399,12
D18S5110,15
D21S1128
FGA24,25
Penta D10,12
Penta E12
TH019.3
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Web pages https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/cov434/
Publications

PubMed=8436435; DOI=10.1002/ijc.2910530415
van den Berg-Bakker C.A.M., Hagemeijer A., Franken-Postma E.M., Smit V.T.H.B.M., Kuppen P.J.K., van Ravenswaay Claasen H.H., Cornelisse C.J., Schrier P.I.
Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.
Int. J. Cancer 53:613-620(1993)

PubMed=9413942; DOI=10.1038/bjc.1997.597; PMCID=PMC2228215
Brouwenstijn N., Slager E.H., Bakker A.B.H., Schreurs M.W.J., van der Spek C.W., Adema G.J., Schrier P.I., Figdor C.G.
Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage.
Br. J. Cancer 76:1562-1566(1997)

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018
Havelock J.C., Rainey W.E., Carr B.R.
Ovarian granulosa cell lines.
Mol. Cell. Endocrinol. 228:67-78(2004)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126.1-2126.10(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=33328126; DOI=10.1016/j.ygyno.2020.12.004; PMCID=PMC10039450
Karnezis A.N., Chen S.Y.-T., Chow C., Yang W., Hendricks W.P.D., Ramos P., Briones N., Mes-Masson A.-M., Bosse T., Gilks C.B., Trent J.M., Weissman B.E., Huntsman D.G., Wang Y.-M.
Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.
Gynecol. Oncol. 160:568-578(2021)

Cross-references
Cell line collections (Providers) ECACC; 07071909
Cell line databases/resources cancercelllines; CVCL_2010
Cell_Model_Passport; SIDM01476
DepMap; ACH-000123
Biological sample resources BioSample; SAMN03473273
BioSample; SAMN10987973
CRISP screens repositories BioGRID_ORCS_Cell_line; 599
Chemistry resources PharmacoDB; COV434_257_2019
Encyclopedic resources Wikidata; Q54814346
Experimental variables resources EFO; EFO_0006384
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM313704
GEO; GSM886964
GEO; GSM888033
Polymorphism and mutation databases Cosmic; 1149408
Cosmic; 1213590
Cosmic; 1429992
Cosmic; 2368539
Cosmic; 2391829
IARC_TP53; 30027
LiGeA; CCLE_469
Progenetix; CVCL_2010
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number32