ID   222TR
AC   CVCL_1T16
DR   cancercelllines; CVCL_1T16
DR   Wikidata; Q54583273
RX   PubMed=1918981;
CC   Problematic cell line: Contaminated. Parent cell line (222) has been shown to be a PA-1 derivative.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro316Pro (c.948C>T); ClinVar=VCV000750727; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C8114; Ovarian mixed germ cell tumor
DI   ORDO; Orphanet_180234; Mixed germ cell tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1T15 ! 222
SX   Female
AG   12Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 05-10-23; Version: 12
//
RX   PubMed=1918981; DOI=10.4049/jimmunol.147.8.2609;
RA   Morimoto H., Safrit J.T., Bonavida B.;
RT   "Synergistic effect of tumor necrosis factor-alpha- and diphtheria
RT   toxin-mediated cytotoxicity in sensitive and resistant human ovarian
RT   tumor cell lines.";
RL   J. Immunol. 147:2609-2616(1991).
//