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Cellosaurus H7D7B (CVCL_1T07)

[Text version]
Cell line name H7D7B
Synonyms H7D7-B
Accession CVCL_1T07
Resource Identification Initiative To cite this cell line use: H7D7B (RRID:CVCL_1T07)
Comments Problematic cell line: Contaminated. Shown to be a Hep-G2 derivative (PubMed=12619888; PubMed=20143388). Originally thought to originate from SV40-transformed normal liver cells.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00204.
Population: Caucasian.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Children:
CVCL_1T10 (H7D7BD5)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): PubMed=12619888

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135815,16
D7S82010
D16S53912,13
D21S1129,31
TH019
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12619888; DOI=10.1023/A:1021653506123
van Pelt J.F., Decorte R., Yap P.S.H., Fevery J.
Identification of HepG2 variant cell lines by short tandem repeat (STR) analysis.
Mol. Cell. Biochem. 243:49-54(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1T07
Biological sample resources BioSample; SAMN03151770
Encyclopedic resources Wikidata; Q54872221
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number19