Cellosaurus logo
expasy logo

Cellosaurus OS 187 (CVCL_1R50)

[Text version]
Cell line name OS 187
Synonyms OS-187; OS187
Accession CVCL_1R50
Resource Identification Initiative To cite this cell line use: OS 187 (RRID:CVCL_1R50)
Comments Problematic cell line: Contaminated. Shown to be a HCT 15 derivative (PubMed=24046071). Originally thought to originate from an osteosarcoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00485.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Arg727Met (c.2180G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Lys993Asn (c.2979G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Ile1417Leufs*2 (c.4248delC); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Arg2166Ter (c.6496C>T); ClinVar=VCV000438883; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; c.68-1G>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Tyr30Ter (c.90C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Cys1200Terfs (c.3599_3600delGT) (3827delGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16627; CHEK2; Simple; p.Arg145Trp (c.433C>T); ClinVar=VCV000005592; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Asp549Asn (c.1645G>A); ClinVar=VCV000375900; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.1101-2A>C; ClinVar=VCV000635383; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0292 (HCT 15)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=15026342; DOI=10.1158/0008-5472.CAN-03-3096
Hughes D.P.M., Thomas D.G., Giordano T.J., Baker L.H., McDonagh K.T.
Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.
Cancer Res. 64:2047-2053(2004)

PubMed=18483362; DOI=10.1158/1078-0432.CCR-07-1992; PMCID=PMC2830718
Zhang P.-Y., Yang Y.-W., Zweidler-McKay P.A., Hughes D.P.M.
Critical role of Notch signaling in osteosarcoma invasion and metastasis.
Clin. Cancer Res. 14:2962-2969(2008)

PubMed=24046071; DOI=10.1158/1078-0432.CCR-13-1914; PMCID=PMC4375543
Zhang P.-Y., Yang Y.-W., Zweidler-McKay P.A., Hughes D.P.M.
Retraction: Critical role of Notch signaling in osteosarcoma invasion and metastasis.
Clin. Cancer Res. 19:5256-5257(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1R50
Biological sample resources BioSample; SAMN03151646
Encyclopedic resources Wikidata; Q54936532
Entry history
Entry creation08-Jul-2015
Last entry update02-May-2024
Version number18