Cellosaurus cell line HEL-R66 (CVCL

Cellosaurus HEL-R66 (CVCL_1R39)

Cross-references
Cell line name	HEL-R66
Synonyms	HELR66
Accession	CVCL_1R39
Resource Identification Initiative	To cite this cell line use: HEL-R66 (RRID:CVCL_1R39)
Comments	Group: Non-human primate cell line. Problematic cell line: Misidentified. Originally thought to be an embryonic lung cell line of human origin but found to be from Chlorocebus aethiops (PubMed=6451928; PubMed=7236009; PubMed=20143388). Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00065. Virology: Highly susceptible to infection by herpes simplex virus types 1 and 2, vaccinia virus, Newcastle disease virus (NDV), Japanese encephalitis virus (JEV), western equine encephalitis virus, Sindbis virus, vesicular stomatitis virus (VSV) and rabies virus (PubMed=116626; PubMed=218901).
Species of origin	Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) (NCBI Taxonomy: 9534)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Undefined cell line type
Web pages	https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=116626; DOI=10.1007/BF01317506 Taguchi F., Toba M., Tada A. Establishment of a permanent cell line (HEL-R66) from human embryonic lung cells with high susceptibility to viruses. Brief report. Arch. Virol. 60:347-351(1979) PubMed=218901; DOI=10.1159/000149037 Toba M., Suzuki H., Sekine N. Absence of interferon production in a newly established human cell line. Intervirology 11:221-226(1979) PubMed=6451928; DOI=10.1126/science.6451928 Nelson-Rees W.A., Daniels D.W., Flandermeyer R.R. Cross-contamination of cells in culture. Science 212:446-452(1981) PubMed=7236009; DOI=10.1007/BF01314608 Nelson-Rees W.A., Daniels D.W., Flandermeyer R.R. Human embryonic lung cells (HEL-R66) are of monkey origin. Arch. Virol. 67:101-104(1981) PubMed=20143388; DOI=10.1002/ijc.25242 Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I. Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Biological sample resources	BioSample; SAMN03152012
Encyclopedic resources	Wikidata; Q54882507
Entry history
Entry creation	08-Jul-2015
Last entry update	10-Sep-2024
Version number	12