ID   NP-2/CD4/CCR5
AC   CVCL_1R27
SY   NP2/CD4/CCR5; NP2-CD4/CCR5; NP2/CD4/R5; NP-2/CD4/EcoVR/CCR5
DR   cancercelllines; CVCL_1R27
DR   RCB; RCB5307
DR   Wikidata; Q54930951
RX   DOI=10.2974/kmj.62.1;
RX   PubMed=10623723;
RX   PubMed=11112502;
RX   PubMed=18577234;
RX   PubMed=22178016;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>T); ClinVar=VCV000634770; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1678; CD4.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Brain, left frontal lobe; UBERON=UBERON_0002811.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1R18 ! NP-2/CD4
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 12
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RX   DOI=10.2974/kmj.62.1;
RA   Hoshino H.;
RT   "The NP-2 cell system for analyses of the coreceptor usage of human
RT   and simian immunodeficiency viruses.";
RL   Kitakanto Med. J. 62:1-14(2012).
//
RX   PubMed=10623723; DOI=10.1128/JVI.74.2.619-626.2000; PMCID=PMC111581;
RA   Shimizu N., Soda Y., Kanbe K., Liu H.-Y., Mukai R., Kitamura T.,
RA   Hoshino H.;
RT   "A putative G protein-coupled receptor, RDC1, is a novel coreceptor
RT   for human and simian immunodeficiency viruses.";
RL   J. Virol. 74:619-626(2000).
//
RX   PubMed=11112502; DOI=10.1006/viro.2000.0623;
RA   Liu H.-Y., Soda Y., Shimizu N., Haraguchi Y., Jinno-Oue A., Takeuchi Y.,
RA   Hoshino H.;
RT   "CD4-dependent and CD4-independent utilization of coreceptors by human
RT   immunodeficiency viruses type 2 and simian immunodeficiency viruses.";
RL   Virology 278:276-288(2000).
//
RX   PubMed=18577234; DOI=10.1186/1742-4690-5-52; PMCID=PMC2453146;
RA   Shimizu N., Tanaka A., Mori T., Ohtsuki T., Hoque A., Jinno-Oue A.,
RA   Apichartpiyakul C., Kusagawa S., Takebe Y., Hoshino H.;
RT   "A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for
RT   primary isolates of human immunodeficiency virus.";
RL   Retrovirology 5:52.1-52.14(2008).
//
RX   PubMed=22178016; DOI=10.1016/j.micinf.2011.11.005;
RA   Hoque S.A., Ohtsuki T., Tatsumi M., Shimizu N., Islam S.,
RA   Jinno-Oue A., Hoshino H.;
RT   "Lack of the trans-receptor mechanism of HIV-1 infection: CD4- and
RT   coreceptor-independent incorporation of HIV-1-resistant cells into
RT   syncytia induced by HIV-1.";
RL   Microbes Infect. 14:357-368(2012).
//