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Cellosaurus J-Lat Tat-GFP Clone A1 (CVCL_1G42)

[Text version]
Cell line name J-Lat Tat-GFP Clone A1
Synonyms J-Lat tat-GFP A1
Accession CVCL_1G42
Resource Identification Initiative To cite this cell line use: J-Lat Tat-GFP Clone A1 (RRID:CVCL_1G42)
Comments Population: Caucasian.
Virology: Latently infected with a GFP-tagged HIV-1 strain. The integrated HIV-1 genome is located in chromosome X (PubMed=28086908).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=12682019; DOI=10.1093/emboj/cdg188; PMCID=PMC154479
Jordan A., Bisgrove D., Verdin E.
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.
EMBO J. 22:1868-1877(2003)

PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U.
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-9852
Cell line databases/resources cancercelllines; CVCL_1G42
Encyclopedic resources Wikidata; Q54898423
Entry history
Entry creation08-Jul-2015
Last entry update10-Sep-2024
Version number18