| Cell line name |
J-Lat Tat-GFP Clone 82 |
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| Synonyms |
J-Lat tat-GFP 82 |
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| Accession |
CVCL_1G41 |
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| Resource Identification Initiative |
To cite this cell line use: J-Lat Tat-GFP Clone 82 (RRID:CVCL_1G41) |
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| Comments |
Population: Caucasian.
Virology: Latently infected with a GFP-tagged HIV-1 strain. The integrated HIV-1 genome is located in chromosome 10 (PubMed=28086908).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 1XF1B; GFP (Note=avGFP; original A.victoria green fluorescent protein).
Misspelling: J-Lat tat-GFP 8.2; PubMed=28086908.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0065 (Jurkat) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=12682019; DOI=10.1093/emboj/cdg188; PMCID=PMC154479
Jordan A., Bisgrove D., Verdin E.
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.
EMBO J. 22:1868-1877(2003) PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Symons J., Chopra A., Malatinkova E., De Spiegelaere W., Leary S., Cooper D., Abana C.O., Rhodes A., Rezaei S.D., Vandekerckhove L., Mallal S., Lewin S.R., Cameron P.U.
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017) |
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| Cross-references |
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| Cell line collections (Providers) |
BEI_Resources; ARP-9851
|
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| Cell line databases/resources |
cancercelllines; CVCL_1G41
|
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| Encyclopedic resources |
Wikidata; Q54898422
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| Entry history |
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| Entry creation | 08-Jul-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 19 |
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