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Cellosaurus U251-TR3 (CVCL_1G29)

[Text version]
Cell line name U251-TR3
Synonyms A172TR3; TR3
Accession CVCL_1G29
Resource Identification Initiative To cite this cell line use: U251-TR3 (RRID:CVCL_1G29)
Comments Problematic cell line: Misidentified. Originally thought (PubMed=19584161) to be a A-172 (Cellosaurus=CVCL_0131) derivative but shown to be a U-251MG derivative (DOI=10.1158/1078-0432.CCR-13-1821).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00523.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:72564; Temozolomide (TMZ).
Derived from sampling site: Brain; parietal lobe.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0021 (U-251MG)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=19584161; DOI=10.1158/1078-0432.CCR-08-3012
Yip S., Miao J., Cahill D.P., Iafrate A.J., Aldape K., Nutt C.L., Louis D.N.
MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.
Clin. Cancer Res. 15:4622-4629(2009)

DOI=10.1158/1078-0432.CCR-13-1821
Yip S., Miao J., Cahill D.P., Iafrate A.J., Aldape K., Nutt C.L., Louis D.N.
Corrections: MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.
Clin. Cancer Res. 19:4543-4544(2013)

Cross-references
Biological sample resources BioSample; SAMN06481106
Encyclopedic resources Wikidata; Q54973630
Polymorphism and mutation databases Cosmic; 1236361
Entry history
Entry creation08-Jul-2015
Last entry update21-Mar-2023
Version number19