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Cellosaurus U251-TR3 (CVCL_1G29)

[Text version]
Cell line name U251-TR3
Synonyms A172TR3; TR3
Accession CVCL_1G29
Resource Identification Initiative To cite this cell line use: U251-TR3 (RRID:CVCL_1G29)
Comments Problematic cell line: Misidentified. Originally thought (PubMed=19584161) to be a A-172 (Cellosaurus=CVCL_0131) derivative but shown to be a U-251MG derivative (DOI=10.1158/1078-0432.CCR-13-1821).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00523.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_72564; Temozolomide (TMZ).
Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0021 (U-251MG)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=19584161; DOI=10.1158/1078-0432.CCR-08-3012; PMCID=PMC2737355
Yip S., Miao J.-Y., Cahill D.P., Iafrate A.J., Aldape K.D., Nutt C.L., Louis D.N.
MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.
Clin. Cancer Res. 15:4622-4629(2009)

DOI=10.1158/1078-0432.CCR-13-1821
Yip S., Miao J.-Y., Cahill D.P., Iafrate A.J., Aldape K.D., Nutt C.L., Louis D.N.
Corrections: MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.
Clin. Cancer Res. 19:4543-4544(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1G29
Biological sample resources BioSample; SAMN06481106
Encyclopedic resources Wikidata; Q54973630
Polymorphism and mutation databases Cosmic; 1236361
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number24