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Cellosaurus Jurkat-HXBc2(6) (CVCL_1F95)

[Text version]
Cell line name Jurkat-HXBc2(6)
Accession CVCL_1F95
Resource Identification Initiative To cite this cell line use: Jurkat-HXBc2(6) (RRID:CVCL_1F95)
Comments Population: Caucasian.
Characteristics: Expresses HIV-1 Rev and Env when tetracycline is removed from the medium. Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04578; HIV-1 isolate HXB2 env.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04618; HIV-1 isolate HXB2 rev.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0065 (Jurkat)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=8627650; DOI=10.1128/JVI.70.3.1340-1354.1996; PMCID=PMC189953
Cao J., Park I.-W., Cooper A., Sodroski J.G.
Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1.
J. Virol. 70:1340-1354(1996)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-3953 - Discontinued
Cell line databases/resources cancercelllines; CVCL_1F95
Encyclopedic resources Wikidata; Q54899158
Entry history
Entry creation08-Jul-2015
Last entry update10-Sep-2024
Version number17