Cellosaurus logo
expasy logo

Cellosaurus A2780-TC1 (CVCL_1F93)

[Text version]
Cell line name A2780-TC1
Synonyms A2780 TC1; A2780TC1; TC1
Accession CVCL_1F93
Resource Identification Initiative To cite this cell line use: A2780-TC1 (RRID:CVCL_1F93)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Omics: Proteome analysis by 2D-DE/MS.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=12815160; DOI=10.1124/mol.64.1.51
Ferlini C., Raspaglio G., Mozzetti S., Distefano M., Filippetti F., Martinelli E., Ferrandina G., Gallo D., Ranelletti F.O., Scambia G.
Bcl-2 down-regulation is a novel mechanism of paclitaxel resistance.
Mol. Pharmacol. 64:51-58(2003)

PubMed=19714814; DOI=10.1021/pr800856b
Cicchillitti L., Di Michele M., Urbani A., Ferlini C., Donati M.B., Scambia G., Rotilio D.
Comparative proteomic analysis of paclitaxel sensitive A2780 epithelial ovarian cancer cell line and its resistant counterpart A2780TC1 by 2D-DIGE: the role of ERp57.
J. Proteome Res. 8:1902-1912(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1F93
Encyclopedic resources Wikidata; Q54606582
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number13