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Cellosaurus JLTRG-R5 (CVCL_1E02)

[Text version]
Cell line name JLTRG-R5
Synonyms Jurkat LTR-GFP CCR5+
Accession CVCL_1E02
Resource Identification Initiative To cite this cell line use: JLTRG-R5 (RRID:CVCL_1E02)
Comments Population: Caucasian.
Virology: Reporter cell line that expresses eGFP as a direct and quantitative marker of HIV-1 infection. The expression of eGFP is under the control of a HIV-1 LTR.
Doubling time: 24-48 hours (BEI_Resources=ARP-11586).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1E01 (JLTRG)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=16454046; DOI=10.2144/000112072
Ochsenbauer-Jambor C., Jones J., Heil M., Zammit K.P., Kutsch O.
T-cell line for HIV drug screening using EGFP as a quantitative marker of HIV-1 replication.
BioTechniques 40:91-100(2006)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-11586
Cell line databases/resources cancercelllines; CVCL_1E02
Encyclopedic resources Wikidata; Q54898985
Entry history
Entry creation08-Jul-2015
Last entry update10-Sep-2024
Version number18