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Cellosaurus TB1A2 (CVCL_1D84)

[Text version]
Cell line name TB1A2
Accession CVCL_1D84
Resource Identification Initiative To cite this cell line use: TB1A2 (RRID:CVCL_1D84)
Comments Characteristics: Deficient in the expression of SYK (PubMed=8691151).
Transformant: ChEBI; CHEBI_232042; Beta-chloro-N-isopropyl-2-naphthaleneethanamine hydrochloride (ICI 42464).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Basophil; CL=CL_0000767.
Disease Rat leukemia (NCIt: C60428)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar; RS=RS:0000955.
Hierarchy Parent: CVCL_0591 (RBL-2H3)
Category Cancer cell line
Web pages http://www.ott.nih.gov/erma/tb1a2-cells-are-defective-protein-tyrosine-kinase-syk-immunoglobulin-ige-receptor-induced
Publications

PubMed=8691151; DOI=10.1084/jem.184.1.71; PMCID=PMC2192664
Zhang J., Berenstein E.H., Evans R.L., Siraganian R.P.
Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells.
J. Exp. Med. 184:71-79(1996)

Cross-references
Encyclopedic resources Wikidata; Q54971747
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number7