ID   KB-A1
AC   CVCL_1D82
SY   KB-A-1; KBA 1; KBA1
DR   Wikidata; Q54899546
RX   PubMed=2897240;
RX   PubMed=3711108;
RX   PubMed=15202936;
CC   Problematic cell line: Contaminated. Grand-parent cell line (KB) has been shown to be a HeLa derivative.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2088 ! KB-3-1
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 14
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RX   PubMed=15202936; DOI=10.1042/BA20040058;
RA   Ren, Yu-Hong
RA   Wei, Dong-Zhi
RA   Zhan, Xiao-Yun
RT   "Inhibition of P-glycoprotein and increasing of drug-sensitivity of a
RT   human carcinoma cell line (KB-A-1) by an antisense
RT   oligodeoxynucleotide-doxorubicin conjugate in vitro.";
RL   Biotechnol. Appl. Biochem. 41:137-143(2005).
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RX   PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X;
RA   Shen, Ding-Wu
RA   Cardarelli, Carol O.
RA   Hwang, Jaulang
RA   Cornwell, Marilyn
RA   Richert, Nancy
RA   Ishii, Shunsuke
RA   Pastan, Ira
RA   Gottesman, Michael Marc
RT   "Multiple drug-resistant human KB carcinoma cells independently
RT   selected for high-level resistance to colchicine, adriamycin, or
RT   vinblastine show changes in expression of specific proteins.";
RL   J. Biol. Chem. 261:7762-7770(1986).
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RX   PubMed=2897240; DOI=10.1016/0092-8674(88)90568-5;
RA   Choi, Kyunghee
RA   Chen, Chang-Jie
RA   Kriegler, Michael
RA   Roninson, Igor B.
RT   "An altered pattern of cross-resistance in multidrug-resistant human
RT   cells results from spontaneous mutations in the mdr1 (P-glycoprotein)
RT   gene.";
RL   Cell 53:519-529(1988).
//