ID   UOK262
AC   CVCL_1D72
SY   UOK-262; UOK 262
DR   BTO; BTO_0005727
DR   Wikidata; Q54991416
RX   PubMed=19963135;
RX   PubMed=21907923;
RX   PubMed=22867999;
RX   PubMed=27993170;
WW   http://www.ott.nih.gov/erma/uok-262-hereditary-leiomyomatosis-and-renal-cell-carcinoma-hlrcc-cell-line
CC   Sequence variation: Mutation; HGNC; HGNC:3700; FH; Simple; p.Gln439Pro (c.1316A>C); Zygosity=Hemizygous (PubMed=19963135).
CC   Derived from site: Metastatic; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C51302; Hereditary leiomyomatosis and renal cell carcinoma
DI   ORDO; Orphanet_523; Hereditary leiomyomatosis and renal cell cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 12
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RX   PubMed=19963135; DOI=10.1016/j.cancergencyto.2009.08.018; PMCID=PMC2827193;
RA   Yang Y.-F., Valera V.A., Padilla-Nash H.M., Sourbier C., Vocke C.D.,
RA   Vira M.A., Abu-Asab M.S., Bratslavsky G., Tsokos M.G., Merino M.J.,
RA   Pinto P.A., Srinivasan R., Ried T., Neckers L., Linehan W.M.;
RT   "UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary
RT   leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an
RT   aberrant energy metabolic pathway in human cancer.";
RL   Cancer Genet. Cytogenet. 196:45-55(2010).
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RX   PubMed=21907923; DOI=10.1016/j.ccr.2011.07.018; PMCID=PMC3174047;
RA   Tong W.-H., Sourbier C., Kovtunovych G., Jeong S.Y., Vira M.A., Ghosh M.,
RA   Romero V.V., Sougrat R., Vaulont S., Viollet B., Kim Y.-S., Lee S.,
RA   Trepel J.B., Srinivasan R., Bratslavsky G., Yang Y.-F., Linehan W.M.,
RA   Rouault T.A.;
RT   "The glycolytic shift in fumarate-hydratase-deficient kidney cancer
RT   lowers AMPK levels, increases anabolic propensities and lowers
RT   cellular iron levels.";
RL   Cancer Cell 20:315-327(2011).
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RX   PubMed=22867999; DOI=10.1016/j.cancergen.2012.05.001; PMCID=PMC3415708;
RA   Yang Y.-F., Valera V.A., Sourbier C., Vocke C.D., Wei M.-H., Pike L.,
RA   Huang Y., Merino M.J., Bratslavsky G., Wu M., Ricketts C.J.,
RA   Linehan W.M.;
RT   "A novel fumarate hydratase-deficient HLRCC kidney cancer cell line,
RT   UOK268: a model of the Warburg effect in cancer.";
RL   Cancer Genet. 205:377-390(2012).
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RX   PubMed=27993170; DOI=10.1186/s12943-016-0565-8; PMCID=PMC5168717;
RA   Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C.,
RA   Czarnecka A.M.;
RT   "Choosing the right cell line for renal cell cancer research.";
RL   Mol. Cancer 15:83.1-83.15(2016).
//