Cellosaurus logo
expasy logo

Cellosaurus MCF-7/182R-7 (CVCL_1D41)

[Text version]
Cell line name MCF-7/182R-7
Synonyms MCF7/182R-7; 182R-7
Accession CVCL_1D41
Resource Identification Initiative To cite this cell line use: MCF-7/182R-7 (RRID:CVCL_1D41)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:31638; Fulvestrant (ICI 182780).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7759159; DOI=10.1002/ijc.2910610417
Lykkesfeldt A.E., Larsen S.S., Briand P.
Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment.
Int. J. Cancer 61:529-534(1995)

PubMed=16172194; DOI=10.1677/erc.1.00946
Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., Lykkesfeldt A.E.
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

Cross-references
Cell line collections (Providers) CancerTools; 152106
ECACC; 16022502 - Discontinued
Ximbio; 152106
Cell line databases/resources cancercelllines; CVCL_1D41
Encyclopedic resources Wikidata; Q54904344
Entry history
Entry creation08-Jul-2015
Last entry update10-Sep-2024
Version number17