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Cellosaurus HROC46 T0 M1 (CVCL_1D21)

[Text version]
Cell line name HROC46 T0 M1
Synonyms HROC46
Accession CVCL_1D21
Resource Identification Initiative To cite this cell line use: HROC46 T0 M1 (RRID:CVCL_1D21)
Comments From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Characteristics: Established from a patient-derived xenograft established in female NOD SCID mice.
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A7UP ! B-LCL-HROC46
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811,13 (Direct_author_submission)
13 (PubMed=25926053)
D7S8208,11
D13S31712
D16S53912,13
D21S1128,32.2
TH016,9.3 (PubMed=25926053)
6,10 (Direct_author_submission)
TPOX8,11 (Direct_author_submission)
8,12 (PubMed=25926053)
vWA15,17

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Publications

PubMed=25309914; DOI=10.1155/2014/568693; PMCID=PMC4182691
Lange F., Franz B., Maletzki C., Linnebacher M., Huhns M., Jaster R.
Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
BioMed Res. Int. 2014:568693.1-568693.13(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300824
Encyclopedic resources Wikidata; Q54895296
Gene expression databases GEO; GSM1448084
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number18