ID   90-8
AC   CVCL_1B47
SY   MPNST 90-8TL; 90-8TL; NF90-8; NF190-8
DR   EFO; EFO_0006288
DR   cancercelllines; CVCL_1B47
DR   Wikidata; Q54605631
RX   PubMed=1568246;
RX   PubMed=7522538;
RX   PubMed=10791998;
RX   PubMed=16239399;
RX   PubMed=16510576;
RX   PubMed=21481793;
RX   PubMed=28469964;
RX   PubMed=32076030;
RX   PubMed=32642732;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.96+1G>A (IVS3+1G>A); ClinVar=VCV000860797; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=7522538).
ST   Source(s): PubMed=32076030
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8
ST   D16S539: 9
ST   D18S51: 14,18
ST   D21S11: 30
ST   D3S1358: 15,21
ST   D5S818: 11
ST   D7S820: 11
ST   D8S1179: 10,12
ST   FGA: 25
ST   Penta D: 14
ST   Penta E: 5,10
ST   TH01: 6
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   NCIt; C3273; Neurofibromatosis type 1
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_636; Neurofibromatosis type 1
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 15
//
RX   PubMed=1568246; DOI=10.1016/0092-8674(92)90407-4;
RA   DeClue J.E., Papageorge A.G., Fletcher J.A., Diehl S.R., Ratner N.,
RA   Vass W.C., Lowy D.R.;
RT   "Abnormal regulation of mammalian p21ras contributes to malignant
RT   tumor growth in von Recklinghausen (type 1) neurofibromatosis.";
RL   Cell 69:265-273(1992).
//
RX   PubMed=7522538; DOI=10.1002/gcc.2870100405;
RA   Legius E., Dierick H., Wu R., Hall B.K., Marynen P., Cassiman J.-J.,
RA   Glover T.W.;
RT   "TP53 mutations are frequent in malignant NF1 tumors.";
RL   Genes Chromosomes Cancer 10:250-255(1994).
//
RX   PubMed=10791998; DOI=10.1172/JCI7610; PMCID=PMC315438;
RA   DeClue J.E., Heffelfinger S.C., Benvenuto G., Ling B., Li S.-W., Rui W.,
RA   Vass W.C., Viskochil D., Ratner N.;
RT   "Epidermal growth factor receptor expression in neurofibromatosis type
RT   1-related tumors and NF1 animal models.";
RL   J. Clin. Invest. 105:1233-1241(2000).
//
RX   PubMed=16239399; DOI=10.1124/jpet.105.091454;
RA   Mattingly R.R., Kraniak J.M., Dilworth J.T., Mathieu P., Bealmear B.,
RA   Nowak J.E., Benjamins J.A., Tainsky M.A., Reiners J.J. Jr.;
RT   "The mitogen-activated protein kinase/extracellular signal-regulated
RT   kinase kinase inhibitor PD184352 (CI-1040) selectively induces
RT   apoptosis in malignant schwannoma cell lines.";
RL   J. Pharmacol. Exp. Ther. 316:456-465(2006).
//
RX   PubMed=16510576; DOI=10.1158/0008-5472.CAN-05-3330;
RA   Miller S.J., Rangwala F., Williams J., Ackerman P., Kong S.,
RA   Jegga A.G., Kaiser S., Aronow B.J., Frahm S., Kluwe L., Mautner V.-F.,
RA   Upadhyaya M., Muir D.F. 4th, Wallace M.R., Hagen J., Quelle D.E.,
RA   Watson M.A., Perry A., Gutmann D.H., Ratner N.;
RT   "Large-scale molecular comparison of human Schwann cells to malignant
RT   peripheral nerve sheath tumor cell lines and tissues.";
RL   Cancer Res. 66:2584-2591(2006).
//
RX   PubMed=21481793; DOI=10.1016/j.ccr.2011.02.017; PMCID=PMC3075552;
RA   Yi C.-L., Troutman S., Fera D., Stemmer-Rachamimov A.O., Avila J.L.,
RA   Christian N., Persson N.L., Shimono A., Speicher D.W., Marmorstein R.,
RA   Holmgren L., Kissil J.L.;
RT   "A tight junction-associated merlin-angiomotin complex mediates
RT   merlin's regulation of mitogenic signaling and tumor suppressive
RT   functions.";
RL   Cancer Cell 19:527-540(2011).
//
RX   PubMed=28469964; PMCID=PMC5411799;
RA   Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R.,
RA   Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C.,
RA   Field J.;
RT   "Comprehensive pharmacological profiling of neurofibromatosis cell
RT   lines.";
RL   Am. J. Cancer Res. 7:923-934(2017).
//
RX   PubMed=32076030; DOI=10.1038/s41598-020-59789-4; PMCID=PMC7031337;
RA   Amirnasr A., Verdijk R.M., van Kuijk P.F., Kartal P., Vriends A.L.M.,
RA   French P.J., van Royen M.E., Taal W., Sleijfer S., Wiemer E.A.C.;
RT   "Deregulated microRNAs in neurofibromatosis type 1 derived malignant
RT   peripheral nerve sheath tumors.";
RL   Sci. Rep. 10:2927-2927(2020).
//
RX   PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054;
RA   Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.;
RT   "Genetics of human malignant peripheral nerve sheath tumors.";
RL   Neurooncol. Adv. 2:i50-i61(2020).
//