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Cellosaurus COLO 720E (CVCL_1995)

[Text version]
Cell line name COLO 720E
Synonyms COLO 720 E; COLO-720E; COLO720E; Colo720E; Colorado 720E
Accession CVCL_1995
Resource Identification Initiative To cite this cell line use: COLO 720E (RRID:CVCL_1995)
Comments Problematic cell line: Partially contaminated. Some stocks are contaminated by COLO 704 (Cellosaurus=CVCL_AV69).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00438.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala138Val (c.413C>T); ClinVar=VCV000184863; Zygosity=Heterozygous (PubMed=24023729).
  • Mutation; HGNC; 11998; TP53; Simple; c.1118delA; Zygosity=Heterozygous (PubMed=24023729).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1863 ! COLO 720L
Sex of cell Female
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): PubMed=22710073

Markers:
AmelogeninX
CSF1PO11,13
D2S133818,24
D3S135815,17
D5S81810,11
D7S82010
D8S117910,13
D13S3178,11
D16S53911
D18S5112,16
D19S43313,15.2
D21S1128,32.2
FGA21,25
TH019
TPOX11
vWA14

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=24023729; DOI=10.1371/journal.pone.0072162; PMCID=PMC3762837
Anglesio M.S., Wiegand K.C., Melnyk N., Chow C., Salamanca C.M., Prentice L.M., Senz J., Yang W., Spillman M.A., Cochrane D.R., Shumansky K., Shah S.P., Kalloger S.E., Huntsman D.G.
Type-specific cell line models for type-specific ovarian cancer research.
PLoS ONE 8:E72162-E72162(2013)

Cross-references
Cell line databases/resources CLO; CLO_0002556
CLDB; cl845
cancercelllines; CVCL_1995
Encyclopedic resources Wikidata; Q54814141
Gene expression databases GEO; GSM711727
Polymorphism and mutation databases Cosmic; 688126
Cosmic; 1707568
IARC_TP53; 21240
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26