ID COLO 699 AC CVCL_1992 SY COLO-699; Colo-699; COLO #699; Colo699; COLO699; Colorado 699; CHL1DM DR BTO; BTO_0003017 DR CLO; CLO_0002574 DR EFO; EFO_0006374 DR CLDB; cl868 DR ArrayExpress; E-MTAB-2706 DR BioSample; SAMN03473074 DR BioSample; SAMN10989575 DR cancercelllines; CVCL_1992 DR Cell_Model_Passport; SIDM00911 DR Cosmic; 844591 DR Cosmic; 877394 DR Cosmic; 1028946 DR Cosmic; 1146950 DR Cosmic; 1152489 DR DepMap; ACH-001041 DR DSMZ; ACC-196 DR DSMZCellDive; ACC-196 DR EGA; EGAS00001000610 DR GEO; GSM434300 DR GEO; GSM886946 DR GEO; GSM888014 DR IGRhCellID; COLO699GEO DR PharmacoDB; COLO699_230_2019 DR PRIDE; PXD002556 DR Progenetix; CVCL_1992 DR Wikidata; Q54814138 RX PubMed=10908148; RX PubMed=11668190; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26361996; RX PubMed=26589293; RX PubMed=31068700; CC Problematic cell line: Contaminated. Shown to be a CHL-1 (or RPMI-7932) derivative (DSMZ=ACC-196; DepMap=ACH-001041). Originally thought to originate from the pleural effusion of a 57 year old female patient with lung adenocarcinoma. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Population: Caucasian. CC Doubling time: ~38 hours (DSMZ=ACC-196). CC HLA typing: A*02:01,02:01; B*07:02,37:04; C*06:02,07:02 (PubMed=26589293). CC Sequence variation: Gene fusion; HGNC; HGNC:2352; CREM + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-CREM (DepMap=ACH-001041). CC Sequence variation: Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Ile228Val (c.682A>G); Zygosity=Heterozygous (DepMap=ACH-001041). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (DepMap=ACH-001041). CC Omics: Genomics; Whole exome sequencing. CC Omics: Proteomics. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Discontinued: DSMZ; ACC-196; true. CC Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): DSMZ=ACC-196; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 10 ST D13S317: 11 ST D16S539: 12 ST D18S51: 11,12 ST D19S433: 15 ST D21S11: 29,30 ST D2S1338: 18 ST D3S1358: 15,17 ST D5S818: 11,12 ST D7S820: 11,13 ST D8S1179: 10,13 ST FGA: 23 ST Penta D: 12,14 ST Penta E: 10,13 ST TH01: 9,9.3 ST TPOX: 8 ST vWA: 17 DI NCIt; C3224; Melanoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_1122 ! CHL-1 SX Female AG 36Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 32 // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003; RA Grundner-Culemann, Kathrin RA Dybowski, J. Nikolaj RA Klammer, Martin RA Tebbe, Andreas RA Schaab, Christoph RA Daub, Henrik RT "Comparative proteome analysis across non-small cell lung cancer cell RT lines."; RL J. Proteomics 130:1-10(2016). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=10908148; DOI=10.1038/labinvest.3780108; RA Speicher, Michael R. RA Petersen, Simone RA Uhrig, Sabine RA Jentsch, Isabell RA Fauth, Christine RA Eils, Roland RA Petersen, Iver RT "Analysis of chromosomal alterations in non-small cell lung cancer by RT multiplex-FISH, comparative genomic hybridization, and multicolor bar RT coding."; RL Lab. Invest. 80:1031-1041(2000). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=11668190; DOI=10.1177/002215540104901105; RA Quentmeier, Hilmar RA Osborn, Mary RA Reinhardt, Julia RA Zaborski, Margarete RA Drexler, Hans Gunther RT "Immunocytochemical analysis of cell lines derived from solid RT tumors."; RL J. Histochem. Cytochem. 49:1369-1378(2001). //