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Cellosaurus A2780cis (CVCL_1942)

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Cell line name A2780cis
Synonyms A2780Cis; A2780CIS; A2780_CIS; A2780 CIS
Accession CVCL_1942
Resource Identification Initiative To cite this cell line use: A2780cis (RRID:CVCL_1942)
Comments Part of: OCCP ovarian cancer cell line panel.
Population: African American.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Array-based CGH.
Omics: CRISPR phenotypic screen.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (PubMed=25230021).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): AddexBio=C0017003/4911; ECACC=93112517; PubMed=11416159; PubMed=25230021

Markers:
AmelogeninX
CSF1PO10,11
D2S133821,23
D3S135813,16
D5S81811
D7S82010
D8S117915,18
D13S31713
D16S53911,13
D18S5116,17
D19S43312
D21S1128
FGA19,24
Penta D8,9
Penta E10,13
TH016
TPOX8,10
vWA15,16

Run an STR similarity search on this cell line
Web pages http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=A2780_CIS
Publications

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=18273836; DOI=10.1002/gcc.20547
Prasad M., Bernardini M., Tsalenko A., Marrano P., Paderova J., Lee C.-H., Ben-Dor A., Barrett M.T., Squire J.A.
High definition cytogenetics and oligonucleotide aCGH analyses of cisplatin-resistant ovarian cancer cells.
Genes Chromosomes Cancer 47:427-436(2008)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Marcotte R., Brown K.R., Suarez Saiz F.J., Sayad A., Karamboulas K., Krzyzanowski P.M., Sircoulomb F., Medrano M., Fedyshyn Y., Koh J.L.-Y., van Dyk D., Fedyshyn B., Luhova M., Brito G.C., Vizeacoumar F.J., Vizeacoumar F.S., Datti A., Kasimer D., Buzina A., Mero P., Misquitta C., Normand J., Haider M., Ketela T., Wrana J.L., Rottapel R., Neel B.G., Moffat J.
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Medrano M., Communal L., Brown K.R., Iwanicki M., Normand J., Paterson J., Sircoulomb F., Krzyzanowski P.M., Novak M., Doodnauth S.A., Suarez Saiz F.J., Cullis J., Al-awar R., Neel B.G., McPherson J., Drapkin R.I., Ailles L., Mes-Masson A.-M., Rottapel R.
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=34071702; DOI=10.3390/ijms22115814; PMCID=PMC8198185
Golan Berman H., Chauhan P., Shalev S., Hassanain H., Parnas A., Adar S.
Genomic characterization of cisplatin response uncovers priming of cisplatin-induced genes in a resistant cell line.
Int. J. Mol. Sci. 22:5814.1-5814.14(2021)

Cross-references
Cell line collections (Providers) AddexBio; C0017003/4911
CancerTools; 152708
ECACC; 93112517 - Discontinued
Ximbio; 152708
Cell line databases/resources CLO; CLO_0001573
CLDB; cl195
cancercelllines; CVCL_1942
Cell_Model_Passport; SIDM01212
LINCS_LDP; LCL-1696
CRISP screens repositories BioGRID_ORCS_Cell_line; 827
Chemistry resources ChEMBL-Cells; CHEMBL4295428
PubChem_Cell_line; CVCL_1942
Encyclopedic resources Wikidata; Q54606614
Gene expression databases GEO; GSM827456
GEO; GSM1291128
GEO; GSM2474972
Polymorphism and mutation databases Progenetix; CVCL_1942
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number29