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Cellosaurus A2780ADR (CVCL_1941)

[Text version]
Cell line name A2780ADR
Synonyms A2780-ADR; A2780 ADR
Accession CVCL_1941
Resource Identification Initiative To cite this cell line use: A2780ADR (RRID:CVCL_1941)
Comments Part of: OCCP ovarian cancer cell line panel.
Population: African American.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: CRISPR phenotypic screen.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (PubMed=25230021).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC=93112520; PubMed=11416159; PubMed=25230021

Markers:
AmelogeninX
CSF1PO10,11
D2S133821,22
D3S135814,16
D5S81811,12
D7S82010
D8S117914,15,16,17 (PubMed=25230021)
15,16,17 (PubMed=11416159)
D13S31713
D16S53911,14
D18S5115
D19S43312
D21S1128
FGA19,25
Penta D8,9
Penta E10,13
TH016 (ECACC=93112520; PubMed=25230021)
6,9.3 (PubMed=11416159)
TPOX8,9
vWA15,16

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Publications

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

Cross-references
Cell line collections (Providers) CancerTools; 152707
ECACC; 93112520 - Discontinued
Ximbio; 152707
Cell line databases/resources CLO; CLO_0001572
cancercelllines; CVCL_1941
Cell_Model_Passport; SIDM01211
LINCS_LDP; LCL-1694
CRISP screens repositories BioGRID_ORCS_Cell_line; 826
Chemistry resources ChEMBL-Cells; CHEMBL3988401
PubChem_Cell_line; CVCL_1941
Encyclopedic resources Wikidata; Q54606613
Gene expression databases GEO; GSM827329
GEO; GSM1291127
Polymorphism and mutation databases Cosmic; 1139224
Progenetix; CVCL_1941
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number28