ID   YNH-1
AC   CVCL_1927
DR   BioSample; SAMN03473442
DR   cancercelllines; CVCL_1927
DR   Cosmic; 787488
DR   Cosmic; 975314
DR   Cosmic; 996309
DR   Cosmic; 998745
DR   Cosmic; 1037657
DR   Cosmic; 1106592
DR   Cosmic; 1281364
DR   Cosmic; 1295724
DR   Cosmic; 2089649
DR   DSMZ; ACC-692
DR   DSMZCellDive; ACC-692
DR   RCB; RCB1291
DR   Wikidata; Q54995460
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=9096702;
RX   PubMed=10354136;
RX   PubMed=10637496;
RX   PubMed=14504097;
RX   PubMed=16518851;
RX   PubMed=23955599;
CC   Population: Japanese.
CC   Doubling time: 82 hours (PubMed=9096702); ~80 hours (DSMZ=ACC-692).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:4010; FUS; Name(s)=FUS-ERG, TLS-ERG (PubMed=9096702; PubMed=10354136).
CC   Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Glu76Gly (c.227A>G); ClinVar=VCV000013338; Zygosity=Unspecified (PubMed=16518851).
CC   Discontinued: RCB; RCB1291; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-692; Technion Genomics Center
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D10S1248: 12,13
ST   D12S391: 17,20
ST   D13S317: 8,13
ST   D16S539: 9
ST   D18S51: 14,15
ST   D19S433: 14
ST   D1S1656: 17
ST   D21S11: 29,30
ST   D22S1045: 15,16
ST   D2S1338: 20,25
ST   D2S441: 9.1,11
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 11,13
ST   D8S1179: 12,13 (Technion Genomics Center)
ST   D8S1179: 13 (DSMZ=ACC-692)
ST   DYS391: 11
ST   FGA: 19,20
ST   Penta D: 11,12
ST   Penta E: 5,11
ST   TH01: 6,9
ST   TPOX: 11,12
ST   vWA: 14,16
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 27
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=9096702; DOI=10.1038/sj.leu.2400594;
RA   Yamamoto K., Hamaguchi H., Nagata K., Kobayashi M., Tanimoto F.,
RA   Taniwaki M.;
RT   "Establishment of a novel human acute myeloblastic leukemia cell line
RT   (YNH-1) with t(16;21), t(1;16) and 12q13 translocations.";
RL   Leukemia 11:599-608(1997).
//
RX   PubMed=10354136; DOI=10.1046/j.1365-2141.1999.01384.x;
RA   Shikami M., Miwa H., Nishii K., Takahashi T., Shiku H., Tsutani H.,
RA   Oka K., Hamaguchi H., Kyo T., Tanaka K., Kamada N., Kita K.;
RT   "Myeloid differentiation antigen and cytokine receptor expression on
RT   acute myelocytic leukaemia cells with t(16;21)(p11;q22): frequent
RT   expression of CD56 and interleukin-2 receptor alpha chain.";
RL   Br. J. Haematol. 105:711-719(1999).
//
RX   PubMed=10637496; DOI=10.1038/sj.leu.2401604;
RA   Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H.,
RA   Uphoff C.C.;
RT   "p53 alterations in human leukemia-lymphoma cell lines: in
RT   vitro artifact or prerequisite for cell immortalization?";
RL   Leukemia 14:198-206(2000).
//
RX   PubMed=14504097; DOI=10.1182/blood-2003-02-0418;
RA   Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R.,
RA   Tsuchida M., Sugita K., Ida K., Hayashi Y.;
RT   "FLT3 mutations in the activation loop of tyrosine kinase domain are
RT   frequently found in infant ALL with MLL rearrangements and pediatric
RT   ALL with hyperdiploidy.";
RL   Blood 103:1085-1088(2004).
//
RX   PubMed=16518851; DOI=10.1002/gcc.20322;
RA   Chen Y.-Y., Takita J., Hiwatari M., Igarashi T., Hanada R., Kikuchi A.,
RA   Hongo T., Taki T., Ogasawara M., Shimada A., Hayashi Y.;
RT   "Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and
RT   pediatric hematological malignancies.";
RL   Genes Chromosomes Cancer 45:583-591(2006).
//
RX   PubMed=23955599; DOI=10.1038/ng.2731;
RA   Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y.,
RA   Yoshida K.-i., Okuno Y., Bando M., Nakato R., Ishikawa S.,
RA   Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D.,
RA   Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K.,
RA   Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M.,
RA   Nakamaki T., Ishiyama K., Nolte F., Hofmann W.-K., Miyawaki S.,
RA   Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H.,
RA   Haferlach T., Shirahige K., Miyano S., Ogawa S.;
RT   "Recurrent mutations in multiple components of the cohesin complex in
RT   myeloid neoplasms.";
RL   Nat. Genet. 45:1232-1237(2013).
//