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Cellosaurus FL (CVCL_1905)

[Text version]
Cell line name FL
Synonyms FL*; FL (HeLa derivative)
Accession CVCL_1905
Secondary accession CVCL_2900
Resource Identification Initiative To cite this cell line use: FL (RRID:CVCL_1905)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=1246601; PubMed=20143388). Originally thought to originate from a normal amnion.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00046.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Genome sequenced (low read coverage).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): ATCC; ECACC; IZSLER

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8208,12
D13S31712,13.3 (ATCC)
12,14 (ECACC; IZSLER)
D16S5399,10
D21S1127,28
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=13408317; DOI=10.3181/00379727-94-23003
Fogh J., Lund R.O.
Continuous cultivation of epithelial cell strain (FL) from human amniotic membrane.
Proc. Soc. Exp. Biol. Med. 94:532-537(1957)

PubMed=5668122; DOI=10.3181/00379727-128-33119
Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R.
Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures determined by sucrose-agar gel and cellulose acetate zymograms.
Proc. Soc. Exp. Biol. Med. 128:772-776(1968)

DOI=10.1007/BF02618370
Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

DOI=10.1007/978-1-4757-1647-4_13
Biedler J.L.
Chromosome abnormalities in human tumor cells in culture.
(In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975)

PubMed=1246601; DOI=10.1126/science.1246601
Nelson-Rees W.A., Flandermeyer R.R.
HeLa cultures defined.
Science 191:96-98(1976)

PubMed=8397027
Ogura H., Yoshinouchi M., Kudo T., Imura M., Fujiwara T., Yabe Y.
Human papillomavirus type 18 DNA in so-called HEP-2, KB and FL cells -- further evidence that these cells are HeLa cell derivatives.
Cell. Mol. Biol. 39:463-467(1993)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=23925245; DOI=10.1038/nature12064
Adey A., Burton J.N., Kitzman J.O., Hiatt J.B., Lewis A.P., Martin B.K., Qiu R.-L., Lee C., Shendure J.
The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line.
Nature 500:207-211(2013)

Cross-references
Cell line collections (Providers) ATCC; CCL-62
CCLV; CCLV-RIE 0012
ECACC; 90111910
IZSLER; BS CL 46
JCRB; JCRB9016 - Discontinued
Cell line databases/resources CLO; CLO_0003358
CLDB; cl1365
CLDB; cl1366
CLDB; cl1367
TOKU-E; 1269
Anatomy/cell type resources BTO; BTO:0003130
Biological sample resources BioSample; SAMN03151695
Encyclopedic resources Wikidata; Q54834949
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27