Cellosaurus logo
expasy logo

Cellosaurus TOM-1 (CVCL_1895)

[Text version]
Cell line name TOM-1
Synonyms TOM1
Accession CVCL_1895
Resource Identification Initiative To cite this cell line use: TOM-1 (RRID:CVCL_1895)
Comments Population: Japanese.
Doubling time: ~60-70 hours (DSMZ=ACC-578).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
Disease Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C114819)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-578

Markers:
AmelogeninX
CSF1PO10,11
D2S133818
D3S135816,17
D5S81811,13
D7S82010,12
D8S117913,14
D13S3178,11
D16S5399,10
D18S5113,15
D19S43314,15
D21S1131,33.2
FGA19,23
Penta D10,12
Penta E11,18
TH017,9
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=3103721; DOI=10.1182/blood.V69.4.990.990
Okabe M., Matsushima S., Morioka M., Kobayashi M., Abe S., Sakurada K., Kakinuma M., Miyazaki T.
Establishment and characterization of a cell line, TOM-1, derived from a patient with Philadelphia chromosome-positive acute lymphocytic leukemia.
Blood 69:990-998(1987)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=1884023; DOI=10.1182/blood.V78.6.1574.1574
Okabe M., Kunieda Y., Sugiwura T., Tanaka M., Miyagishima T., Saiki I., Minagawa T., Kurosawa M., Itaya T., Miyazaki T.
Inhibitory effect of interleukin-4 on the in vitro growth of Ph1-positive acute lymphoblastic leukemia cells.
Blood 78:1574-1580(1991)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

Cross-references
Cell line collections (Providers) DSMZ; ACC-578
Cell line databases/resources DSMZCellDive; ACC-578
Biological sample resources BioSample; SAMN03473484
Encyclopedic resources Wikidata; Q54972778
Gene expression databases GEO; GSM236808
GEO; GSM236844
Polymorphism and mutation databases Cosmic; 1012125
Cosmic; 1026577
Cosmic; 1524825
Cosmic; 2491093
Cosmic; 2649234
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number25