Cellosaurus cell line RO (CVCL

Cellosaurus RO (CVCL_1886)

[Text version]

Cell line name

Synonyms

Ro; Robert

Accession

CVCL_1886

Resource Identification Initiative

To cite this cell line use: RO (RRID:CVCL_1886)

Comments

Doubling time: ~50-60 hours (DSMZ=ACC-452).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Mutation; HGNC; HGNC:9986; RFX5; Simple; p.Arg294Ter (c.880C>T); ClinVar=VCV001431893; Zygosity=Homozygous (PubMed=7744245).
Mutation; HGNC; HGNC:9986; RFX5; Simple; p.Pro409Arg (c.1226C>G); ClinVar=VCV000292612; Zygosity=Homozygous (PubMed=7744245).

Disease

Bare lymphocyte syndrome type 2 (NCIt: C171268)
Immunodeficiency by defective expression of MHC class II (ORDO: Orphanet_572)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

Category

Transformed cell line

STR profile

Source(s): DSMZ=ACC-452

Markers:

Amelogenin	X,Y
CSF1PO	10,12
D2S1338	20,21
D3S1358	14,15
D5S818	12,13
D7S820	11,12
D8S1179	13,14
D13S317	11,12
D16S539	10,12
D18S51	14,15
D19S433	14
D21S11	28,29
FGA	19,23
Penta D	9,12
Penta E	12,16
TH01	7,8
TPOX	8,10
vWA	17,18

Publications

PubMed=3133120; DOI=10.1016/S0092-8674(88)90389-3
Reith W., Satola S.W., Herrero Sanchez C., Amaldi I., Lisowska-Grospierre B., Griscelli C., Hadam M.R., Mach B.
Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X.
Cell 53:897-906(1988)

PubMed=7744245; DOI=10.1101/gad.9.9.1021
Steimle V., Durand B., Barras E., Zufferey M., Hadam M.R., Mach B., Reith W.
A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).
Genes Dev. 9:1021-1032(1995)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-452

Cell line databases/resources

DSMZCellDive; ACC-452

Biological sample resources

BioSample; SAMN03473551

Encyclopedic resources

Wikidata; Q54950785

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number