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Cellosaurus OCI-Ly18 (CVCL_1880)

[Text version]
Cell line name OCI-Ly18
Synonyms OCI-LY18; OCI-LY-18; OCILY18; OCI-Ly 18; Ly18; LY18
Accession CVCL_1880
Secondary accession CVCL_9551
Resource Identification Initiative To cite this cell line use: OCI-Ly18 (RRID:CVCL_1880)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Ontario Cancer Institute (OCI); Toronto; Canada.
Doubling time: ~30-40 hours (DSMZ=ACC-699).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: miRNA expression profiling.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Misspelling: OCI-LZ18; BioSample=SAMN03473448.
Misspelling: SU-DHL-18; Cosmic=1295513.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (DepMap=ACH-001616).
Disease Diffuse large B-cell lymphoma (NCIt: C8851)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001616; DSMZ=ACC-699

Markers:
AmelogeninX
CSF1PO10,12
D2S133818,24
D3S135814,15
D5S81811,12
D7S82010,12
D8S117910,13
D13S31710,12
D16S53911,13
D18S5115,19
D19S43313,14
D21S1131
FGA19,21
Penta D10
Penta E5,14
TH016,9
TPOX8,11
vWA15,19

Run an STR similarity search on this cell line
Web pages http://www.innovationbridge.com/uhn/diffuse-large-b-cell-lymphoma-cell-lines?categories=32&communities=5&forums=&organizations=&tags=
Publications

PubMed=1311715; DOI=10.1172/JCI115642; PMCID=PMC442951
Chang H., Messner H.A., Wang X.-H., Yee C., Addy L., Meharchand J., Minden M.D.
A human lymphoma cell line with multiple immunoglobulin rearrangements.
J. Clin. Invest. 89:1014-1020(1992)

PubMed=8574164; DOI=10.3109/10428199509059672
Chang H., Blondal J.A., Benchimol S., Minden M.D., Messner H.A.
p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines.
Leuk. Lymphoma 19:165-171(1995)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11807979; DOI=10.1002/gcc.10025
Mehra S., Messner H.A., Minden M.D., Chaganti R.S.K.
Molecular cytogenetic characterization of non-Hodgkin lymphoma cell lines.
Genes Chromosomes Cancer 33:225-234(2002)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Green M.R., Monti S., Rodig S.J., Juszczynski P., Currie T., O'Donnell E., Chapuy B., Takeyama K., Neuberg D., Golub T.R., Kutok J.L., Shipp M.A.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=26727417; DOI=10.3109/10428194.2015.1108414
Drexler H.G., Eberth S., Nagel S., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.
Leuk. Lymphoma 57:1015-1020(2016)

Cross-references
Cell line collections (Providers) DSMZ; ACC-699
Cell line databases/resources cancercelllines; CVCL_1880
DepMap; ACH-001616
DSMZCellDive; ACC-699
Biological sample resources BioSample; SAMN03473448
Chemistry resources ChEMBL-Cells; CHEMBL4523522
ChEMBL-Targets; CHEMBL4523553
PubChem_Cell_line; CVCL_1880
Encyclopedic resources Wikidata; Q54931770
Gene expression databases GEO; GSM380131
GEO; GSM552456
GEO; GSM1374785
Polymorphism and mutation databases Cosmic; 1295513
Cosmic; 1517651
Cosmic; 1541906
Cosmic; 1636683
Cosmic; 2276334
Progenetix; CVCL_1880
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number29