ID   BT-B [Human HeLa contaminated cell line]
AC   CVCL_1858
DR   CLO; CLO_0002045
DR   CLDB; cl500
DR   BioSample; SAMN03151668
DR   BioSample; SAMN03470925
DR   Cosmic; 905951
DR   DSMZ; ACC-227
DR   DSMZCellDive; ACC-227
DR   Wikidata; Q54798477
RX   PubMed=2108047;
RX   PubMed=8230540;
RX   PubMed=11668190;
RX   PubMed=25877200;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (DSMZ=ACC-227). Originally thought to originate from the a 66 year old Caucasian man with a malignant urinary bladder carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00394.
CC   Population: African American.
CC   Doubling time: ~43 hours (DSMZ=ACC-227).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Discontinued: DSMZ; ACC-227; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13,14
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 18,21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 26
//
RX   PubMed=2108047; DOI=10.1016/0014-4827(90)90080-T;
RA   van der Bosch J., Ruller S., Horn D., Schumann R., Schlaak M.;
RT   "Density-dependent tumor cell death and reversible cell cycle arrest:
RT   mutually exclusive modes of monocyte-mediated growth control.";
RL   Exp. Cell Res. 187:185-192(1990).
//
RX   PubMed=8230540; DOI=10.1016/S0022-5347(17)35941-4;
RA   Bohle A., Thanhauser A., Ulmer A.J., Ernst M., Flad H.-D., Jocham D.;
RT   "Dissecting the immunobiological effects of Bacillus Calmette-Guerin
RT   (BCG) in vitro: evidence of a distinct BCG-activated killer (BAK) cell
RT   phenomenon.";
RL   J. Urol. 150:1932-1937(1993).
//
RX   PubMed=11668190; DOI=10.1177/002215540104901105;
RA   Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.;
RT   "Immunocytochemical analysis of cell lines derived from solid
RT   tumors.";
RL   J. Histochem. Cytochem. 49:1369-1378(2001).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//