ID   NALM-21
AC   CVCL_1837
SY   NALM21
DR   ArrayExpress; E-MTAB-11038
DR   ArrayExpress; E-MTAB-11039
DR   Cosmic; 999738
DR   DSMZ; ACC-682
DR   DSMZCellDive; ACC-682
DR   JCRB; JCRB1825
DR   Wikidata; Q54907402
RX   PubMed=1817649;
RX   PubMed=8139288;
RX   PubMed=9680106;
RX   PubMed=10071072;
RX   PubMed=34940123;
CC   Population: Japanese.
CC   Doubling time: ~50 hours (DSMZ=ACC-682).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): DSMZ=ACC-682; JCRB=JCRB1825
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8,12
ST   D16S539: 9,10
ST   D18S51: 16,17
ST   D19S433: 13,14
ST   D21S11: 30,31.2
ST   D2S1338: 18,24
ST   D3S1358: 14,15
ST   D5S818: 11,13
ST   D7S820: 10,12
ST   D8S1179: 11,16
ST   FGA: 20,21
ST   Penta D: 11,13
ST   Penta E: 9,18
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C114819; Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_L054 ! B250
OI   CVCL_1836 ! NALM-20
OI   CVCL_5662 ! NALM-22
OI   CVCL_5663 ! NALM-23
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
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RX   PubMed=1817649;
RA   Matsuo Y., Ariyasu T., Ohmoto E., Kimura I., Minowada J.;
RT   "Bi-phenotypic t(9;22)-positive leukemia cell lines from a patient
RT   with acute leukemia: NALM-20, established at the onset; and NALM-21,
RT   NALM-22 and NALM-23, established after relapse.";
RL   Hum. Cell 4:335-338(1991).
//
RX   PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x;
RA   Sato S., Honma Y., Hozumi M., Hayashi Y., Matsuo Y., Shibata K.,
RA   Omura S., Hino K.-i., Tomoyasu S., Tsuruoka N.;
RT   "Effects of herbimycin A and its derivatives on growth and
RT   differentiation of Ph1-positive acute lymphoid leukemia cell lines.";
RL   Leuk. Res. 18:221-228(1994).
//
RX   PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2;
RA   Matsuo Y., Drexler H.G.;
RT   "Establishment and characterization of human B cell precursor-leukemia
RT   cell lines.";
RL   Leuk. Res. 22:567-579(1998).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001;
RA   Quentmeier H., Pommerenke C., Drexler H.G.;
RT   "Molecular genetics of pre-B acute lymphoblastic leukemia sister cell
RT   lines during disease progression.";
RL   Curr. Issues Mol. Biol. 43:2147-2156(2021).
//