ID   NALM-20
AC   CVCL_1836
SY   NALM20
DR   BTO; BTO_0004934
DR   ArrayExpress; E-MTAB-11038
DR   ArrayExpress; E-MTAB-11039
DR   BioSample; SAMN03473435
DR   Cosmic; 996290
DR   Cosmic; 998700
DR   Cosmic; 999766
DR   Cosmic; 1037714
DR   DSMZ; ACC-681
DR   DSMZCellDive; ACC-681
DR   JCRB; JCRB1823
DR   Wikidata; Q54907401
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1817649;
RX   PubMed=8139288;
RX   PubMed=9680106;
RX   PubMed=10071072;
RX   PubMed=10233379;
RX   PubMed=14504097;
RX   PubMed=34940123;
CC   Population: Japanese.
CC   Doubling time: ~72 hours (PubMed=1817649); ~60-80 hours (DSMZ=ACC-681).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=1817649; PubMed=10071072).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-681; JCRB=JCRB1823
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8,12
ST   D16S539: 9,10
ST   D18S51: 16,17
ST   D19S433: 13,14
ST   D21S11: 30,31.2
ST   D2S1338: 18,24
ST   D3S1358: 14,15
ST   D5S818: 11,13
ST   D7S820: 10,12
ST   D8S1179: 11,16
ST   FGA: 20,21
ST   Penta D: 11,13
ST   Penta E: 9,18
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C114819; Adult B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_L054 ! B250
OI   CVCL_1837 ! NALM-21
OI   CVCL_5662 ! NALM-22
OI   CVCL_5663 ! NALM-23
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1817649;
RA   Matsuo Y., Ariyasu T., Ohmoto E., Kimura I., Minowada J.;
RT   "Bi-phenotypic t(9;22)-positive leukemia cell lines from a patient
RT   with acute leukemia: NALM-20, established at the onset; and NALM-21,
RT   NALM-22 and NALM-23, established after relapse.";
RL   Hum. Cell 4:335-338(1991).
//
RX   PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x;
RA   Sato S., Honma Y., Hozumi M., Hayashi Y., Matsuo Y., Shibata K.,
RA   Omura S., Hino K.-i., Tomoyasu S., Tsuruoka N.;
RT   "Effects of herbimycin A and its derivatives on growth and
RT   differentiation of Ph1-positive acute lymphoid leukemia cell lines.";
RL   Leuk. Res. 18:221-228(1994).
//
RX   PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2;
RA   Matsuo Y., Drexler H.G.;
RT   "Establishment and characterization of human B cell precursor-leukemia
RT   cell lines.";
RL   Leuk. Res. 22:567-579(1998).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10233379; DOI=10.1111/j.1365-2141.1999.01284.x;
RA   Xu F., Taki T., Yang H.W., Hanada R., Hongo T., Ohnishi H.,
RA   Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.;
RT   "Tandem duplication of the FLT3 gene is found in acute lymphoblastic
RT   leukaemia as well as acute myeloid leukaemia but not in
RT   myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in
RT   children.";
RL   Br. J. Haematol. 105:155-162(1999).
//
RX   PubMed=14504097; DOI=10.1182/blood-2003-02-0418;
RA   Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R.,
RA   Tsuchida M., Sugita K., Ida K., Hayashi Y.;
RT   "FLT3 mutations in the activation loop of tyrosine kinase domain are
RT   frequently found in infant ALL with MLL rearrangements and pediatric
RT   ALL with hyperdiploidy.";
RL   Blood 103:1085-1088(2004).
//
RX   PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001;
RA   Quentmeier H., Pommerenke C., Drexler H.G.;
RT   "Molecular genetics of pre-B acute lymphoblastic leukemia sister cell
RT   lines during disease progression.";
RL   Curr. Issues Mol. Biol. 43:2147-2156(2021).
//