Cellosaurus cell line MEGAL (CVCL

Cellosaurus MEGAL (CVCL_1833)

[Text version]

Cell line name

MEGAL

Accession

CVCL_1833

Resource Identification Initiative

To cite this cell line use: MEGAL (RRID:CVCL_1833)

Comments

Part of: LL-100 blood cancer cell line panel.
Doubling time: ~70 hours (DSMZ=ACC-719).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.

Sequence variations

Gene fusion; HGNC; 8064; NUP214 + HGNC; 10760; SET; Name(s)=SET-NUP214 (PubMed=19166587).

HLA typing

Source: DSMZCellDive=ACC-719

Class I
HLA-A	A*11:01:01,11:01:01
HLA-B	B*07:02:01,07:02:01
HLA-C	C*07:02:01,07:02:01
Class II
HLA-DP	DPA1*02:01:02,02:01:02
	DPB1*01:01:01,01:01:01
HLA-DQ	DQB1*06:02:01,06:02:01
HLA-DR	DRA*01:02:03,01:02:03
	DRB1*15:01:01,15:01:01

Disease

Acute megakaryoblastic leukemia (NCIt: C3170)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): DSMZ

Markers:

Amelogenin	X
CSF1PO	10,12
D2S1338	17,25
D3S1358	15,17
D5S818	9,12
D7S820	11,12
D8S1179	12
D13S317	12
D16S539	11
D18S51	13,14
D19S433	13,16
D21S11	28,30
FGA	20,23
Penta D	9,10
Penta E	14
TH01	9.3
TPOX	9
vWA	16

Publications

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=19166587; DOI=10.1186/1756-8722-2-3
Quentmeier H., Schneider B., Rohrs S., Romani J., Zaborski M., MacLeod R.A.F., Drexler H.G.
SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines.
J. Hematol. Oncol. 2:3.1-3.5(2009)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-719

Cell line databases/resources

DSMZCellDive; ACC-719

Encyclopedic resources

Wikidata; Q54905040

Gene expression databases

ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722

Polymorphism and mutation databases

Cosmic; 787451
Cosmic; 975269
Cosmic; 1012088
Cosmic; 1281327
Cosmic; 2306218
Cosmic; 2588711

Entry history

Entry creation

04-Apr-2012

Last entry update

21-Mar-2023

Version number