ID   LAMA-87
AC   CVCL_1826
SY   Lama-87; LAMA87
DR   BTO; BTO:0004466
DR   CLO; CLO_0007239
DR   CLDB; cl55
DR   BioSample; SAMN03473337
DR   Cell_Model_Passport; SIDM01230
DR   Cosmic; 787501
DR   DSMZ; ACC-270
DR   DSMZCellDive; ACC-270
DR   Millipore; SCC138
DR   Wikidata; Q54901915
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7996872;
RX   PubMed=9257809;
RX   PubMed=10071072;
RX   PubMed=10576511;
CC   Characteristics: Established after subcutaneous transplantation of parent cells into estrone-treated nude mice.
CC   Doubling time: ~50-60 hours (DSMZ=ACC-270).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys319Ter (c.955A>T); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-270; Millipore=SCC138
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 13
ST   D19S433: 13
ST   D21S11: 29,31
ST   D2S1338: 17
ST   D3S1358: 14,17
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 10,15
ST   FGA: 21,22
ST   Penta D: 10
ST   Penta E: 7
ST   TH01: 6,7
ST   TPOX: 10
ST   vWA: 14,17
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0388 ! LAMA-84
SX   Female
AG   29Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 22
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=7996872; DOI=10.1016/0145-2126(94)90102-3;
RA   Champelovier P., Valiron O., Jacrot M., Leroux D., Seigneurin D.;
RT   "Selection and characterization of an erythroeosinophilic subclone
RT   (LAMA-87) and an eosinophilic subclone (LAMA-88) from the
RT   multipotential cell line LAMA-84.";
RL   Leuk. Res. 18:903-918(1994).
//
RX   PubMed=9257809;
RA   Champelovier P., Fixe P., Valiron O., Feige J.-J., Praloran V.,
RA   Seigneurin D.;
RT   "Proliferation of LAMA-84 and LAMA-87 cell lines is modulated by
RT   autocrine loops involving M-CSF and TGF-beta.";
RL   Exp. Hematol. 25:958-965(1997).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10576511; DOI=10.1016/s0145-2126(99)00131-9;
RA   Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.;
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//