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Cellosaurus Karpas-1106P (CVCL_1821)

[Text version]
Cell line name Karpas-1106P
Synonyms Karpas-1106p; KARPAS-1106P; Karpas 1106P; KARPAS 1106P; KARPAS1106P; Karpas1106P; Karpas-1106; Karpas 1106; Karpas1106; K1106
Accession CVCL_1821
Resource Identification Initiative To cite this cell line use: Karpas-1106P (RRID:CVCL_1821)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: ~60-100 hours (ECACC=06072607).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*03:01,24:02
HLA-BB*35:01,51:01
HLA-CC*04:01,16:02
Class II
HLA-DQDQA1*03:02,05:01
DQB1*03:02,03:02
HLA-DRDRB1*03:17,03:17
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.68
Native American0.48
East Asian, North0.25
East Asian, South1.18
South Asian11.86
European, North19.43
European, South65.12
Disease Primary mediastinal (thymic) large B-cell lymphoma (NCIt: C9280)
Primary mediastinal large B-cell lymphoma (ORDO: Orphanet_98838)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_QY35 ! Karpas-1106A
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1327773; DSMZ=ACC-545; ECACC=06072607; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133817,23
D3S135815
D5S8188,14
D7S8209,13
D8S11798,15
D13S3179,11
D16S5399
D18S5121
D19S43314
D21S1129,30
FGA21,22
Penta D8,11
Penta E7
TH016
TPOX9,11
vWA18,20

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=7949096; DOI=10.1182/blood.V84.10.3422.3422
Nacheva E., Dyer M.J.S., Metivier C., Jadayel D.M., Stranks G., Morilla R., Heward J.M., Holloway T., O'Connor S., Bevan P.C., Larsen C.-J., Karpas A.
B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression.
Blood 84:3422-3428(1994)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., De Lord C.F.M., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=9724100; DOI=10.1002/(SICI)1097-0215(19980925)78:1<100::AID-IJC16>3.0.CO;2-F
Tamura A., Akagi T., Nakazawa N., Kashima K., Nakamura S., Karpas A., Silverman G.A., Morishima Y., Taniwaki M., Seto M.
Delineation of the breakpoint at 18q21.1 in a cell line (Karpas1106) derived from mediastinal B-cell lymphoma by fluorescence in situ hybridization with multiple YAC clones.
Int. J. Cancer 78:100-105(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058
Li C., Kim S.-W., Rai D., Bolla A.R., Adhvaryu S., Kinney M.C., Robetorye R.S., Aguiar R.C.T.
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.
Blood 113:6681-6690(2009)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Green M.R., Monti S., Rodig S.J., Juszczynski P., Currie T., O'Donnell E., Chapuy B., Takeyama K., Neuberg D., Golub T.R., Kutok J.L., Shipp M.A.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-545 - Discontinued
ECACC; 06072607
Cell line databases/resources cancercelllines; CVCL_1821
Cell_Model_Passport; SIDM01011
Cosmic-CLP; 1327773
DepMap; ACH-002254
DSMZCellDive; ACC-545
Lonza; 1123
Biological sample resources BioSample; SAMN03470811
Chemistry resources ChEMBL-Cells; CHEMBL4523588
ChEMBL-Targets; CHEMBL4523591
GDSC; 1327773
PharmacoDB; KARPAS1106P_727_2019
PubChem_Cell_line; CVCL_1821
Encyclopedic resources Wikidata; Q54899481
Experimental variables resources EFO; EFO_0006606
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM119503
GEO; GSM157143
GEO; GSM380128
GEO; GSM552445
GEO; GSM1374584
GEO; GSM1374585
GEO; GSM1669973
GEO; GSM1897961
Polymorphism and mutation databases Cosmic; 1013890
Cosmic; 1278829
Cosmic; 1289975
Cosmic; 2276324
Cosmic; 2297035
Cosmic; 2437271
Cosmic; 2479248
Progenetix; CVCL_1821
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number34