ID   TT
AC   CVCL_1774
SY   MTC-TT
DR   BTO; BTO_0003074
DR   CLO; CLO_0009421
DR   EFO; EFO_0002382
DR   CLDB; cl4547
DR   CLDB; cl4901
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1803
DR   BCRC; 60346
DR   BCRJ; 0259
DR   BioSample; SAMN03471250
DR   BioSample; SAMN10988442
DR   cancercelllines; CVCL_1774
DR   CCRID; 1101HUM-PUMC000268
DR   CCRID; 3101HUMTCHu78
DR   CCRID; 4201HUM-CCTCC00073
DR   CCTCC; GDC0073
DR   Cell_Model_Passport; SIDM00484
DR   ChEMBL-Cells; CHEMBL3308145
DR   ChEMBL-Targets; CHEMBL2366083
DR   CLS; 305027
DR   Cosmic; 796049
DR   Cosmic; 796731
DR   Cosmic; 930299
DR   Cosmic; 1005455
DR   Cosmic; 1094763
DR   Cosmic; 1175889
DR   Cosmic; 1239955
DR   Cosmic; 1608835
DR   Cosmic; 1612901
DR   Cosmic; 1699419
DR   Cosmic; 1876248
DR   Cosmic; 2036697
DR   Cosmic; 2050374
DR   Cosmic-CLP; 930299
DR   DepMap; ACH-001321
DR   ECACC; 92050721
DR   EGA; EGAS00001000978
DR   GDSC; 930299
DR   GEO; GSM887714
DR   GEO; GSM888807
DR   GEO; GSM1374966
DR   GEO; GSM1670548
DR   IARC_TP53; 27017
DR   IARC_TP53; 30182
DR   ICLC; HTL98004
DR   IGRhCellID; TT
DR   KCB; KCB 2013001YJ
DR   LiGeA; CCLE_452
DR   LINCS_LDP; LCL-1690
DR   Lonza; 1097
DR   PharmacoDB; TT_1606_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1774
DR   PubChem_Cell_line; CVCL_1774
DR   Wikidata; Q54973178
RX   CelloPub=CLPUB00116;
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1516062;
RX   PubMed=2519210;
RX   PubMed=3467830;
RX   PubMed=7736432;
RX   PubMed=7864888;
RX   PubMed=9046062;
RX   PubMed=11751535;
RX   PubMed=19897677;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=22538498;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30737244;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=35839778;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/normal-growth-and-morphology-of-atcc-crl-1803-the-tt-cells
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: ~83 hours (ATCC=CRL-1803).
CC   HLA typing: A*02:01,03:01; B*51:01,67:02; C*12:03,14:02; DQB1*05:01,06:07; DRB1*01:01,11:10 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:9967; RET; Simple; p.Cys634Trp (c.1902C>G); ClinVar=VCV000013918; Zygosity=Heterozygous (PubMed=7736432; PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).
CC   Sequence variation: Mutation; HGNC; HGNC:11602; TBX3; Simple; p.Trp197Ter (c.591G>A); Zygosity=Heterozygous (PubMed=30737244; Cosmic-CLP=930299; DepMap=ACH-001321).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=2.11%; Native American=0%; East Asian, North=2.03%; East Asian, South=0%; South Asian=6.11%; European, North=32.67%; European, South=57.09% (PubMed=30894373).
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
CC   Cell type: Parafollicular cell; CL=CL_0000570.
ST   Source(s): ATCC=CRL-1803; CCRID; Cosmic-CLP=930299; ECACC=92050721; ICLC=HTL98004; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 12
ST   D19S433: 14,15
ST   D21S11: 29,32.2
ST   D2S1338: 17,23
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 10,12
ST   D8S1179: 15,16
ST   FGA: 21,25
ST   Penta D: 13
ST   Penta E: 7,13
ST   TH01: 6,9
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C46099; Hereditary thyroid gland medullary carcinoma
DI   NCIt; C123329; Multiple endocrine neoplasia type 2
DI   ORDO; Orphanet_99361; Familial medullary thyroid carcinoma
DI   ORDO; Orphanet_653; Multiple endocrine neoplasia type 2
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 41
//
RX   PubMed=7864888; DOI=10.1006/bbrc.1995.1287;
RA   Carlomagno, Francesca
RA   Salvatore, Domenico
RA   Santoro, Massimo Mattia
RA   de Franciscis, Vittorio
RA   Quadro, Loredano
RA   Panariello, Luigi
RA   Colantuoni, Vittorio
RA   Fusco, Alfredo
RT   "Point mutation of the RET proto-oncogene in the TT human medullary
RT   thyroid carcinoma cell line.";
RL   Biochem. Biophys. Res. Commun. 207:1022-1028(1995).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=19897677; DOI=10.1210/jc.2009-1485; PMCID=PMC2805480;
RA   Zhu, Wen
RA   Hai, Tao
RA   Ye, Lei
RA   Cote, Gilbert J.
RT   "Medullary thyroid carcinoma cell lines contain a self-renewing CD133+
RT   population that is dependent on Ret proto-oncogene activity.";
RL   J. Clin. Endocrinol. Metab. 95:439-444(2010).
//
RX   CelloPub=CLPUB00116;
RA   Leong, Susan S.
RA   Horoszewicz, Julius Stanislaw
RA   Shimaoka, Keiji
RA   Friedmann, M.
RA   Kawinski, Elzbieta
RA   Song, Min Jong
RA   Zeigel, Robert Francis
RA   Chu, Tsann Ming
RA   Baylin, Stephen Bruce
RA   Mirand, Edwin A.
RT   "A new cell line for study of human medullary thyroid carcinoma.";
RL   (In book chapter) Advances in thyroid neoplasia; Andreoli, Mario & Monaco, Fabrizio & Robbins, Jacob (eds.); pp.95-108; Field Educational Italia; Roma; Italy (1981).
//
RX   PubMed=9046062; DOI=10.14670/HH-12.283;
RA   Zabel, Maciej
RA   Grzeszkowiak, Jan
RT   "Characterisation of thyroid medullary carcinoma TT cell line.";
RL   Histol. Histopathol. 12:283-289(1997).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa, Inigo
RA   Pozdeyev, Nikita
RA   Korch, Christopher T.
RA   Marlow, Laura A.
RA   Smallridge, Robert Christian
RA   Copland, John Alton 3rd
RA   Henderson, Ying C.
RA   Lai, Stephen Y.
RA   Clayman, Gary L.
RA   Onoda, Naoyoshi
RA   Tan, Aik-Choon
RA   Garcia-Rendueles, Maria E.R.
RA   Knauf, Jeffrey A.
RA   Haugen, Bryan R.
RA   Fagin, James Alexander
RA   Schweppe, Rebecca E.
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RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey, Thomas E.
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=1516062;
RA   Yoshimoto, Katsuhiko
RA   Iwahana, Hiroyuki
RA   Fukuda, Ayumi
RA   Sano, Toshiaki
RA   Saito, Shiro
RA   Itakura, Mitsuo
RT   "Role of p53 mutations in endocrine tumorigenesis: mutation detection
RT   by polymerase chain reaction-single strand conformation
RT   polymorphism.";
RL   Cancer Res. 52:5061-5064(1992).
//
RX   PubMed=3467830; DOI=10.1016/0165-4608(87)90156-7;
RA   Tanaka, Kimio
RA   Baylin, Stephen Bruce
RA   Nelkin, Barry D.
RA   Testa, Joseph R.
RT   "Cytogenetic studies of a human medullary thyroid carcinoma cell
RT   line.";
RL   Cancer Genet. Cytogenet. 25:27-35(1987).
//
RX   PubMed=11751535; DOI=10.1093/clinchem/48.1.25;
RA   Zammatteo, Nathalie
RA   Lockman, Laurence
RA   Brasseur, Francis
RA   De Plaen, Etienne
RA   Lurquin, Christophe
RA   Lobert, Pierre-Emmanuel
RA   Hamels, Sandrine
RA   Boon, Thierry
RA   Remacle, Jose
RT   "DNA microarray to monitor the expression of MAGE-A genes.";
RL   Clin. Chem. 48:25-34(2002).
//
RX   PubMed=22538498; DOI=10.1159/000338793;
RA   Grozinsky-Glasberg, Simona
RA   Shimon, Ilan
RA   Rubinfeld, Hadara
RT   "The role of cell lines in the study of neuroendocrine tumors.";
RL   Neuroendocrinology 96:173-187(2012).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=2519210;
RA   Kameya, Toru
RA   Kadoya, Kuniko
RA   Iguchi, Haruo
RT   "Characterization and calcitonin secretion of a human well
RT   differentiated C-cell tumor cell line.";
RL   Hum. Cell 2:231-237(1989).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E;
RA   Cooley, Linda D.
RA   Elder, Frederick F.B.
RA   Knuth, Alexander
RA   Gagel, Robert F.
RT   "Cytogenetic characterization of three human and three rat medullary
RT   thyroid carcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 80:138-149(1995).
//