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Cellosaurus TGBC1TKB (CVCL_1769)

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Cell line name TGBC1TKB
Synonyms TGBC-1-TKB; TGBC-1TKB; TGBC1-TKB; TGBC-1; TGBC1
Accession CVCL_1769
Resource Identification Initiative To cite this cell line use: TGBC1TKB (RRID:CVCL_1769)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 41 hours (PubMed=9824643); 45 hours (PubMed=32293552).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176fs*6 (c.525_526insGCGC); Zygosity=Heterozygous (Cosmic-CLP=909769; DepMap=ACH-001861).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.16
East Asian, North75.35
East Asian, South24.48
South Asian0
European, North0
European, South0
Disease Gallbladder undifferentiated carcinoma (NCIt: C9167)
Carcinoma of gallbladder and extrahepatic biliary tract (ORDO: Orphanet_56044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_3339 ! TGBC2TKB
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=909769; DepMap=ACH-001861; RCB=RCB1129

Markers:
AmelogeninX
CSF1PO14
D3S135815
D5S81811
D7S8209,13
D8S117914,16
D13S3178 (DepMap=ACH-001861)
8,11 (Cosmic-CLP=909769; RCB=RCB1129)
D16S5399,11
D18S5114,18
FGA25
Penta D13
Penta E15
TH019
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=21533411; DOI=10.3892/ijo.10.3.545
Moon Y., Dahlberg W.K., Yu Y.-J., Ohno T., Todoroki T., Little J.B.
Radiosensitivity of human biliary tract cancer cell lines in vitro.
Int. J. Oncol. 10:545-551(1997)

PubMed=9824643; DOI=10.3892/ijo.13.6.1269
Koike N., Todoroki T., Kawamoto T., Yoshida S., Kashiwagi H., Fukao K., Ohno T., Watanabe T.
The invasion potentials of human biliary tract carcinoma cell lines: correlation between invasiveness and morphologic characteristics.
Int. J. Oncol. 13:1269-1274(1998)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21451941; DOI=10.1007/s00534-011-0376-7
Sato J., Kimura T., Saito T., Anazawa T., Kenjo A., Sato Y., Tsuchiya T., Gotoh M.
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.
J. Hepatobiliary Pancreat. Sci. 18:700-711(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=32293552; DOI=10.1186/s40659-020-00282-7; PMCID=PMC7158131
Garcia P., Bizama C., Rosa L., Espinoza J.A., Weber H., Cerda-Infante J., Sanchez M., Montecinos V.P., Lorenzo-Bermejo J., Boekstegers F., Davila-Lopez M., Alfaro F., Leiva-Acevedo C., Parra Z., Romero D., Kato S., Leal P., Lagos M., Roa J.C.
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor.
Biol. Res. 53:13.1-13.17(2020)

PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451
Scherer D., Davila-Lopez M., Goeppert B., Abrahamsson S., Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D., Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.
RNA sequencing of hepatobiliary cancer cell lines: data and applications to mutational and transcriptomic profiling.
Cancers (Basel) 12:2510.1-2510.14(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vijay V., Karisani N., Shi L., Hung Y.-H., Vu P., Kattel P., Kenney L., Merritt J., Adil R., Wu Q.-B., Zhen Y.-L., Morris R., Kreuzer J., Kathiresan M., Herrera Lopez X.I., Ellis H., Gritti I.G., Lecorgne L., Farag I., Popa A., Shen W., Kato H., Xu Q., Balasooriya E.R., Wu M.-J., Chaturantabut S., Kelley R.K., Cleary J.M., Lawrence M.S., Root D.E., Benes C.H., Deshpande V., Juric D., Sellers W.R., Ferrone C.R., Haas W., Vazquez F., Getz G., Bardeesy N.M.
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line collections (Providers) RCB; RCB1129
Cell line databases/resources CLO; CLO_0050019
Cell_Model_Passport; SIDM00252
Cosmic-CLP; 909769
DepMap; ACH-001861
LINCS_LDP; LCL-1343
Biological sample resources BioSample; SAMN03472156
Chemistry resources ChEMBL-Cells; CHEMBL3308852
ChEMBL-Targets; CHEMBL2366089
GDSC; 909769
PharmacoDB; TGBC1TKB_1590_2019
PubChem_Cell_line; CVCL_1769
Encyclopedic resources Wikidata; Q54972238
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670540
Polymorphism and mutation databases Cosmic; 909769
IARC_TP53; 27261
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number40