ID   SUP-T1
AC   CVCL_1714
SY   Sup-T1; SUPT-1; SupT-1; Sup T-1; SUP T-1; SUP T1; Sup T1; SupT1; SUPT1; Tsup-1; VB; Stanford University Pediatric T-cell line 1
DR   BTO; BTO:0003582
DR   CLO; CLO_0009164
DR   CLDB; cl4420
DR   CLDB; cl4421
DR   CLDB; cl4422
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1942
DR   BCRC; 60191
DR   BioGRID_ORCS_Cell_line; 456
DR   BioSample; SAMN03471266
DR   BioSample; SAMN03473416
DR   BioSample; SAMN10987655
DR   cancercelllines; CVCL_1714
DR   Cell_Model_Passport; SIDM01154
DR   ChEMBL-Cells; CHEMBL3308368
DR   ChEMBL-Targets; CHEMBL614940
DR   Cosmic; 687855
DR   Cosmic; 909743
DR   Cosmic; 1086322
DR   Cosmic; 1281384
DR   Cosmic; 1330493
DR   Cosmic; 1524822
DR   Cosmic; 1664528
DR   Cosmic; 1760532
DR   Cosmic; 2165716
DR   Cosmic; 2602931
DR   Cosmic-CLP; 909743
DR   DepMap; ACH-000953
DR   DSMZ; ACC-140
DR   DSMZCellDive; ACC-140
DR   ECACC; 95013123
DR   EGA; EGAS00001000978
DR   GDSC; 909743
DR   GEO; GSM482493
DR   GEO; GSM887662
DR   GEO; GSM888754
DR   GEO; GSM1670494
DR   HIVReagentProgram; ARP-100
DR   HIVReagentProgram; ARP-150
DR   ICLC; HTL96007
DR   LiGeA; CCLE_331
DR   LINCS_LDP; LCL-1023
DR   Lonza; 293
DR   PharmacoDB; SUPT1_1522_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1714
DR   PubChem_Cell_line; CVCL_1714
DR   Wikidata; Q54970880
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3004618;
RX   PubMed=3010463;
RX   PubMed=3036367;
RX   PubMed=3107838;
RX   PubMed=3935328;
RX   PubMed=6437672;
RX   PubMed=6438800;
RX   PubMed=7849311;
RX   PubMed=8558920;
RX   PubMed=9933131;
RX   PubMed=11264379;
RX   PubMed=17170727;
RX   PubMed=20164919;
RX   PubMed=22292511;
RX   PubMed=22460905;
RX   PubMed=22675565;
RX   PubMed=25355872;
RX   PubMed=27397505;
RX   PubMed=29304865;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=32938764;
RX   PubMed=35839778;
WW   https://humantallcelllines.wordpress.com/comprehensivetable/sup-t1/
WW   http://www.nibsc.org/Default.aspx?pageid=597&id=0024&theme=default
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Characteristics: Has chromosomal translocations involving the genes for the alpha and beta subunits of TCR thus preventing surface expression of the endogenous TCR complex.
CC   Virology: Useful for studies of cell fusion and cytopathic effects of HIV-1 as well as cytopathic isolates of HIV-2.
CC   Virology: Susceptible to infection by herpesvirus 6B (HHV-6B) strain Z29 (PubMed=29304865).
CC   Doubling time: 28 hours (PubMed=3004618); ~30 hours (DSMZ=ACC-140); ~24-36 hours (HIVReagentProgram=ARP-100).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Microsatellite instability: Instable (MSI) (PubMed=31068700).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
CC   Sequence variation: Mutation; HGNC; 7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
CC   Sequence variation: Mutation; HGNC; 9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
CC   Sequence variation: Mutation; HGNC; 15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743; DepMap=ACH-000953).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=909743).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Omics: Virome analysis using RNAseq.
CC   Genome ancestry: African=0.14%; Native American=1.61%; East Asian, North=0%; East Asian, South=0%; South Asian=9.49%; European, North=46.77%; European, South=41.99% (PubMed=30894373).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC=CRL-1942; Cosmic-CLP=909743; DSMZ=ACC-140; PubMed=32938764
ST   Amelogenin: X (DSMZ=ACC-140)
ST   Amelogenin: X,Y (ATCC=CRL-1942; Cosmic-CLP=909743; PubMed=32938764)
ST   CSF1PO: 10,11 (ATCC=CRL-1942; Cosmic-CLP=909743; DSMZ=ACC-140)
ST   CSF1PO: 10,11,12 (PubMed=32938764)
ST   D13S317: 10,11,12 (DSMZ=ACC-140; PubMed=32938764)
ST   D13S317: 11,12 (ATCC=CRL-1942; Cosmic-CLP=909743)
ST   D16S539: 9,10,11,13 (DSMZ=ACC-140)
ST   D16S539: 9,11,12 (ATCC=CRL-1942; Cosmic-CLP=909743)
ST   D16S539: 9,12 (PubMed=32938764)
ST   D18S51: 13,14
ST   D19S433: 13,27
ST   D21S11: 28,29,32.2,33.2 (DSMZ=ACC-140)
ST   D21S11: 28,31,32,33 (PubMed=32938764)
ST   D2S1338: 25,26
ST   D3S1358: 16,17,18,19 (PubMed=32938764)
ST   D3S1358: 17 (DSMZ=ACC-140)
ST   D5S818: 10,11,12 (DSMZ=ACC-140)
ST   D5S818: 11 (PubMed=32938764)
ST   D5S818: 11,12 (ATCC=CRL-1942; Cosmic-CLP=909743)
ST   D7S820: 11
ST   D8S1179: 13,14 (PubMed=32938764)
ST   D8S1179: 13,14,15 (DSMZ=ACC-140)
ST   FGA: 19,20,21 (PubMed=32938764)
ST   FGA: 20,21 (DSMZ=ACC-140)
ST   Penta D: 12
ST   Penta E: 13,14,16 (PubMed=32938764)
ST   Penta E: 14,16 (DSMZ=ACC-140)
ST   TH01: 9.3
ST   TPOX: 8,9 (DSMZ=ACC-140)
ST   TPOX: 9 (ATCC=CRL-1942; Cosmic-CLP=909743; PubMed=32938764)
ST   vWA: 16,17,18,19 (PubMed=32938764)
ST   vWA: 16,18 (ATCC=CRL-1942; Cosmic-CLP=909743)
ST   vWA: 16,18,19 (DSMZ=ACC-140)
DI   NCIt; C7210; Childhood T lymphoblastic lymphoma
DI   ORDO; Orphanet_171918; T-cell non-Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 41
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=3004618; DOI=10.1182/blood.V67.3.650.650;
RA   Smith S.D., Morgan R., Link M.P., McFall P., Hecht F.;
RT   "Cytogenetic and immunophenotypic analysis of cell lines established
RT   from patients with T cell leukemia/lymphoma.";
RL   Blood 67:650-656(1986).
//
RX   PubMed=3010463; DOI=10.1126/science.3010463;
RA   Lifson J.D., Reyes G.R., McGrath M.S., Stein B.S., Engleman E.G.;
RT   "AIDS retrovirus induced cytopathology: giant cell formation and
RT   involvement of CD4 antigen.";
RL   Science 232:1123-1127(1986).
//
RX   PubMed=3036367; DOI=10.1016/0092-8674(87)90666-0;
RA   Baer R., Forster A., Rabbitts T.H.;
RT   "The mechanism of chromosome 14 inversion in a human T cell
RT   lymphoma.";
RL   Cell 50:97-105(1987).
//
RX   PubMed=3107838; DOI=10.1016/0092-8674(87)90542-3;
RA   Stein B.S., Gowda S.D., Lifson J.D., Penhallow R.C., Bensch K.G.,
RA   Engleman E.G.;
RT   "pH-independent HIV entry into CD4-positive T cells via virus envelope
RT   fusion to the plasma membrane.";
RL   Cell 49:659-668(1987).
//
RX   PubMed=3935328; DOI=10.1016/0092-8674(85)90243-0;
RA   Baer R., Chen K.-C., Smith S.D., Rabbitts T.H.;
RT   "Fusion of an immunoglobulin variable gene and a T cell receptor
RT   constant gene in the chromosome 14 inversion associated with T cell
RT   tumors.";
RL   Cell 43:705-713(1985).
//
RX   PubMed=6437672;
RA   Smith S.D., Shatsky M., Cohen P.S., Warnke R.A., Link M.P., Glader B.E.;
RT   "Monoclonal antibody and enzymatic profiles of human malignant
RT   T-lymphoid cells and derived cell lines.";
RL   Cancer Res. 44:5657-5660(1984).
//
RX   PubMed=6438800; DOI=10.1126/science.6438800;
RA   Hecht F., Morgan R., Kaiser-McCaw Hecht B., Smith S.D.;
RT   "Common region on chromosome 14 in T-cell leukemia and lymphoma.";
RL   Science 226:1445-1447(1984).
//
RX   PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893;
RA   Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R.,
RA   De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L.,
RA   Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D.,
RA   Millar J.L., Catovsky D., Dyer M.J.S.;
RT   "Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
RL   Blood 85:893-901(1995).
//
RX   PubMed=8558920;
RA   Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M.,
RA   Quentmeier H., Drexler H.G.;
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
//
RX   PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7;
RA   Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.;
RT   "Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines:
RT   suggestion for classification by immunophenotype and T-cell receptor
RT   studies.";
RL   Leuk. Res. 23:19-27(1999).
//
RX   PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001;
RA   Means R.E., Matthews T., Hoxie J.A., Malim M.H., Kodama T.,
RA   Desrosiers R.C.;
RT   "Ability of the V3 loop of simian immunodeficiency virus to serve as a
RT   target for antibody-mediated neutralization: correlation of
RT   neutralization sensitivity, growth in macrophages, and decreased
RT   dependence on CD4.";
RL   J. Virol. 75:3903-3915(2001).
//
RX   PubMed=17170727; DOI=10.1038/sj.leu.2404486;
RA   Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M.,
RA   De Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M.,
RA   Langerak A.W.;
RT   "Human T-cell lines with well-defined T-cell receptor gene
RT   rearrangements as controls for the BIOMED-2 multiplex polymerase chain
RT   reaction tubes.";
RL   Leukemia 21:230-237(2007).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22292511; DOI=10.2174/187221512799303172;
RA   Ho P., Dai K.-S., Chen H.-L.;
RT   "Molecular cloning of a novel PPEF-1 gene variant from a T-cell
RT   lymphoblastic lymphoma cell line.";
RL   Recent Pat. DNA Gene Seq. 6:72-77(2012).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22675565; DOI=10.1371/journal.pone.0038463;
RA   Atak Z.K., De Keersmaecker K., Gianfelici V., Geerdens E.,
RA   Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G.,
RA   Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P.,
RA   Cools J., Aerts S.;
RT   "High accuracy mutation detection in leukemia on a selected panel of
RT   cancer genes.";
RL   PLoS ONE 7:E38463-E38463(2012).
//
RX   PubMed=25355872; DOI=10.1128/JVI.02570-14;
RA   Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z.,
RA   O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.;
RT   "High-throughput RNA sequencing-based virome analysis of 50 lymphoma
RT   cell lines from the Cancer Cell Line Encyclopedia project.";
RL   J. Virol. 89:713-729(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29304865; DOI=10.1186/s12985-017-0917-z;
RA   Becerra-Artiles A., Santoro T., Stern L.J.;
RT   "Evaluation of a method to measure HHV-6B infection in vitro based on
RT   cell size.";
RL   Virol. J. 15:4.1-4.15(2018).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.,
RA   Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=32938764; DOI=10.1128/JVI.01334-20;
RA   Fernandez M.V., Hoffman H.K., Pezeshkian N., Tedbury P.R.,
RA   van Engelenburg S.B., Freed E.O.;
RT   "Elucidating the basis for permissivity of the MT-4 T-cell line to
RT   replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail.";
RL   J. Virol. 94:e01334.20.1-e01334.20.27(2020).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//