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Cellosaurus Panc 02.13 (CVCL_1634)

[Text version]
Cell line name Panc 02.13
Synonyms Panc 2.13; Panc-02.13; PANC-02-13; Panc2.13; PANC0213; PL1; PL-1
Accession CVCL_1634
Resource Identification Initiative To cite this cell line use: Panc 02.13 (RRID:CVCL_1634)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Johns Hopkins University School of Medicine; Baltimore; USA.
Population: Caucasian.
Doubling time: 33.9 hours (PubMed=9612602).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000045115; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.03
Native American0.98
East Asian, North0.28
East Asian, South0
South Asian0.04
European, North63.98
European, South32.69
Disease Pancreatic adenocarcinoma (NCIt: C8294)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D3S135816,18
D5S81812
D7S8207,11
D8S117912,13
D13S3178,11
D16S5399,12
D18S5111
D21S1129
FGA21,23
Penta D12
Penta E8,13
TH016,9.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=9612602
Jaffee E.M., Schutte M., Gossett J., Morsberger L.A., Adler A.J., Thomas M., Greten T.F., Hruban R.H., Yeo C.J., Griffin C.A.
Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.
Cancer J. Sci. Am. 4:194-203(1998)

PubMed=14695172
Iacobuzio-Donahue C.A., Ashfaq R., Maitra A., Adsay N.V., Shen-Ong G.L., Berg K., Hollingsworth M.A., Cameron J.L., Yeo C.J., Kern S.E., Goggins M.G., Hruban R.H.
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.
Cancer Res. 63:8614-8622(2003)

PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721
Calhoun E.S., Hucl T., Gallmeier E., West K.M., Arking D.E., Maitra A., Iacobuzio-Donahue C.A., Chakravarti A., Hruban R.H., Kern S.E.
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Cancer Res. 66:7920-7928(2006)

PubMed=18000365; DOI=10.1159/000108295
Griffin C.A., Morsberger L.A., Hawkins A.L., Haddadin M., Patel A., Ried T., Schrock E., Perlman E.J., Jaffee E.M.
Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations.
Cytogenet. Genome Res. 118:148-156(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25167228; DOI=10.1038/bjc.2014.475
Hamidi H., Lu M., Chau K., Anderson L., Fejzo M.S., Ginther C., Linnartz R., Zubel A., Slamon D.J., Finn R.S.
KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.
Br. J. Cancer 111:1788-1801(2014)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-2554
Cell line databases/resources CLO; CLO_0008375
cancercelllines; CVCL_1634
Cell_Model_Passport; SIDM01325
DepMap; ACH-000031
Biological sample resources BioSample; SAMN03472905
BioSample; SAMN10987902
Chemistry resources PharmacoDB; Panc02_13_1240_2019
Encyclopedic resources Wikidata; Q54937515
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887495
GEO; GSM888577
GEO; GSM1024406
Polymorphism and mutation databases IARC_TP53; 28234
LiGeA; CCLE_679
Progenetix; CVCL_1634
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25