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Cellosaurus NCI-H2198 (CVCL_1540)

[Text version]
Cell line name NCI-H2198
Synonyms H2198; H-2198
Accession CVCL_1540
Resource Identification Initiative To cite this cell line use: NCI-H2198 (RRID:CVCL_1540)
Comments Population: Caucasian.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,02:24
HLA-BB*07:02,08:01
HLA-CC*07:01,07:01
Class II
HLA-DQDQA1*02:01,05:02
DQB1*02:01,02:01
HLA-DRDRB1*03:01,07:01
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2655 ! NCI-BL2195
CVCL_1538 ! NCI-H2195
CVCL_1539 ! NCI-H2196
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-5933; PubMed=20679594; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11
D2S133820,21
D3S135815
D5S81812
D7S82010,11
D8S117913
D13S31711
D16S53910
D18S5113,14
D19S43314,15
D21S1130
FGA22
Penta D9,10
Penta E7
TH019.3
TPOX8 (PubMed=25877200)
8,9 (ATCC=CRL-5933; PubMed=20679594)
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)

PubMed=8806103; DOI=10.1002/jcb.240630516
Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. Suppl. 24:210-217(1996)

PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084
Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A., Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., Aldige C.R., Wistuba I.I., Minna J.D.
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
J. Cell. Biochem. 121:3986-3999(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-5933
Cell line databases/resources CLO; CLO_0008064
cancercelllines; CVCL_1540
LINCS_LDP; LCL-1817
Biological sample resources BioSample; SAMN03473227
Chemistry resources PharmacoDB; NCIH2198_1078_2019
Encyclopedic resources Wikidata; Q54907940
Experimental variables resources EFO; EFO_0006677
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM986180
Polymorphism and mutation databases Cosmic; 688017
Cosmic; 877234
Progenetix; CVCL_1540
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number28