ID   ME-180
AC   CVCL_1401
SY   Me-180; ME 180; ME180
DR   CLO; CLO_0007657
DR   CLO; CLO_0050924
DR   EFO; EFO_0006646
DR   CLDB; cl3429
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HTB-33
DR   ATCC; CRL-7932
DR   BioSample; SAMN03471125
DR   BioSample; SAMN03472007
DR   BioSample; SAMN03472511
DR   BioSample; SAMN03473047
DR   cancercelllines; CVCL_1401
DR   CCRID; 3101HUMTCHu177
DR   Cell_Model_Passport; SIDM00627
DR   ChEMBL-Cells; CHEMBL3308114
DR   ChEMBL-Targets; CHEMBL1075499
DR   CLS; 300196
DR   Cosmic; 687514
DR   Cosmic; 760223
DR   Cosmic; 809228
DR   Cosmic; 846185
DR   Cosmic; 877466
DR   Cosmic; 928909
DR   Cosmic; 1071909
DR   Cosmic; 1102582
DR   Cosmic; 1131524
DR   Cosmic; 1175837
DR   Cosmic; 1176609
DR   Cosmic; 1193031
DR   Cosmic; 1995503
DR   Cosmic; 2301541
DR   Cosmic; 2546868
DR   Cosmic; 2660192
DR   Cosmic; 2816215
DR   Cosmic-CLP; 687514
DR   DepMap; ACH-001359
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 687514
DR   GEO; GSM113864
DR   GEO; GSM253300
DR   GEO; GSM595618
DR   GEO; GSM675736
DR   GEO; GSM685436
DR   GEO; GSM827202
DR   GEO; GSM1670090
DR   IARC_TP53; 21490
DR   ICLC; HTL96027
DR   IGRhCellID; ME180%20GEO
DR   JCRB; JCRB0810
DR   KCLB; 30033
DR   LINCS_LDP; LCL-1305
DR   PharmacoDB; ME180_910_2019
DR   PRIDE; PXD003668
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1401
DR   PubChem_Cell_line; CVCL_1401
DR   RCB; RCB2106
DR   TKG; TKG 0437
DR   TOKU-E; 2410
DR   Wikidata; Q54904901
RX   DOI=10.1007/978-1-4757-1647-4_13;
RX   PubMed=77569;
RX   PubMed=327080;
RX   PubMed=833871;
RX   PubMed=2990217;
RX   PubMed=3371749;
RX   PubMed=3518877;
RX   PubMed=4317734;
RX   PubMed=6220172;
RX   PubMed=6500159;
RX   PubMed=6582512;
RX   PubMed=7017212;
RX   PubMed=7459858;
RX   PubMed=7751322;
RX   PubMed=8380785;
RX   PubMed=8931502;
RX   PubMed=9290701;
RX   PubMed=9887230;
RX   PubMed=15531914;
RX   PubMed=17325662;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22710073;
RX   PubMed=24134916;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=27561551;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=35839778;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-612.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Virology: Contains a complete HPV68 genome.
CC   Doubling time: 1.5 days (PubMed=29156801).
CC   HLA typing: A*01,11; B*05,08; C*w07 (PubMed=77569).
CC   HLA typing: A*01:01,32:03; B*08:01,44:02; C*05:01,07:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=9887230).
CC   Transformant: NCBI_TaxID; 45240; Human papillomavirus type 68 (HPV68).
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=1.51%; Native American=0.16%; East Asian, North=1.49%; East Asian, South=0%; South Asian=0%; European, North=64.3%; European, South=32.53% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7932; true.
CC   Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
ST   Source(s): ATCC; CCRID; CLS; Cosmic-CLP; JCRB; KCLB; PubMed=22710073; PubMed=25877200; PubMed=29156801; RCB; TKG
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11,12 (PubMed=22710073)
ST   D13S317: 11,13 (ATCC; CCRID; CLS; Cosmic-CLP; JCRB; KCLB; PubMed=25877200; PubMed=29156801; RCB; TKG)
ST   D16S539: 12,13
ST   D18S51: 12
ST   D19S433: 13,15.2
ST   D21S11: 30,31
ST   D2S1338: 18
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 9,10
ST   D8S1179: 14
ST   FGA: 23
ST   Penta D: 9,14
ST   Penta E: 12,14
ST   TH01: 8 (RCB)
ST   TH01: 8,9.3 (ATCC; CCRID; CLS; Cosmic-CLP; JCRB; KCLB; PubMed=22710073; PubMed=25877200; PubMed=29156801; TKG)
ST   TPOX: 8,10
ST   vWA: 15,16,17 (JCRB)
ST   vWA: 15,17 (ATCC; CCRID; CLS; Cosmic-CLP; KCLB; PubMed=22710073; PubMed=25877200; PubMed=29156801; RCB; TKG)
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 44
//
RX   DOI=10.1007/978-1-4757-1647-4_13;
RA   Biedler J.L.;
RT   "Chromosome abnormalities in human tumor cells in culture.";
RL   (In) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York (1975).
//
RX   PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x;
RA   Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.;
RT   "Tissue typing of cells in culture. III. HLA antigens of established
RT   human cell lines. Attempts at typing by the mixed hemadsorption
RT   technique.";
RL   Tissue Antigens 11:279-286(1978).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=2990217;
RA   Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.;
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=3371749; DOI=10.1016/0090-8258(88)90029-7;
RA   Grenman S.E., Shapira A., Carey T.E.;
RT   "In vitro response of cervical cancer cell lines CaSki, HeLa, and
RT   ME-180 to the antiestrogen tamoxifen.";
RL   Gynecol. Oncol. 30:228-238(1988).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=4317734; DOI=10.1093/jnci/45.1.107;
RA   Sykes J.A., Whitescarver J., Jernstrom P., Nolan J.F., Byatt P.;
RT   "Some properties of a new epithelial cell line of human origin.";
RL   J. Natl. Cancer Inst. 45:107-122(1970).
//
RX   PubMed=6220172;
RA   Dracopoli N.C., Fogh J.;
RT   "Polymorphic enzyme analysis of cultured human tumor cell lines.";
RL   J. Natl. Cancer Inst. 70:469-476(1983).
//
RX   PubMed=6500159; DOI=10.1159/000163283;
RA   Gershwin M.E., Lentz D., Owens R.B.;
RT   "Relationship between karyotype of tissue culture lines and
RT   tumorigenicity in nude mice.";
RL   Exp. Cell Biol. 52:361-370(1984).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568;
RA   Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.;
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=7017212; DOI=10.1093/jnci/66.6.1003;
RA   Pollack M.S., Heagney S.D., Livingston P.O., Fogh J.;
RT   "HLA-A, B, C and DR alloantigen expression on forty-six cultured human
RT   tumor cell lines.";
RL   J. Natl. Cancer Inst. 66:1003-1012(1981).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=7751322; DOI=10.1007/BF01366967;
RA   Rantanen V., Grenman S.E., Kulmala J., Grenman R.;
RT   "The intrinsic radiosensitivity and sublethal damage repair capacity
RT   of five cervical carcinoma cell lines tested with the 96-well-plate
RT   assay.";
RL   J. Cancer Res. Clin. Oncol. 121:230-234(1995).
//
RX   PubMed=8380785; DOI=10.1006/gyno.1993.1016;
RA   Iwasaka T., Oh-uchida M., Matsuo N., Yokoyama M., Fukuda K., Hara K.,
RA   Fukuyama K., Hori K., Sugimori H.;
RT   "Correlation between HPV positivity and state of the p53 gene in
RT   cervical carcinoma cell lines.";
RL   Gynecol. Oncol. 48:104-109(1993).
//
RX   PubMed=8931502; DOI=10.3109/00016349609054706;
RA   Iwasaka T., Zheng P.-S., Ouchida M., Yamasaki H., Yokoyama M.,
RA   Sugimori H.;
RT   "Cytologic changes in two cervical carcinoma cell lines after
RT   transfection of the wild-type p53 gene.";
RL   Acta Obstet. Gynecol. Scand. 75:797-803(1996).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=9887230; DOI=10.1006/gyno.1998.5194;
RA   Rantanen V., Grenman S.E., Kurvinen K., Hietanen S., Raitanen M.,
RA   Syrjanen S.M.;
RT   "p53 mutations and presence of HPV DNA do not correlate with
RT   radiosensitivity of gynecological cancer cell lines.";
RL   Gynecol. Oncol. 71:352-358(1998).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S.,
RA   Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H.,
RA   Schwarte-Waldhoff I.;
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=17325662; DOI=10.1038/sj.onc.1210330;
RA   Nakaya K., Yamagata H.D., Arita N., Nakashiro K.-i., Nose M., Miki T.,
RA   Hamakawa H.;
RT   "Identification of homozygous deletions of tumor suppressor gene FAT
RT   in oral cancer using CGH-array.";
RL   Oncogene 26:5300-5308(2007).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017;
RA   Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K.,
RA   Lessey B.A., Jordan V.C., Bradford A.P.;
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=24134916; DOI=10.1186/1755-8166-6-44;
RA   McCormack A., Fan J.-L., Duesberg M., Bloomfield M., Fiala C.,
RA   Duesberg P.H.;
RT   "Individual karyotypes at the origins of cervical carcinomas.";
RL   Mol. Cytogenet. 6:44.1-44.23(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=27561551; DOI=10.1038/ncomms12645;
RA   Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.Y.,
RA   Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.;
RT   "Integrative proteomic profiling of ovarian cancer cell lines reveals
RT   precursor cell associated proteins and functional status.";
RL   Nat. Commun. 7:12645.1-12645.14(2016).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//