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Cellosaurus Lu-165 (CVCL_1391)

[Text version]
Cell line name Lu-165
Synonyms LU-165; LU165
Accession CVCL_1391
Resource Identification Initiative To cite this cell line use: Lu-165 (RRID:CVCL_1391)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Indonesian.
Characteristics: Produces high level of vasopressin.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly36Arg (c.106G>A); ClinVar=VCV001334551; Zygosity=Heterozygous (Cosmic-CLP=753589; DepMap=ACH-002077).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157Profs*9 (c.468_480delCGTCCGCGCCATG); Zygosity=Heterozygous (Cosmic-CLP=753589; DepMap=ACH-002077).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.53
East Asian, North28.73
East Asian, South70.74
South Asian0
European, North0
European, South0
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753589; RCB=RCB1184

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S8189,13
D7S82012
D13S31710
D16S5399,11
TH019
TPOX8,9
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=8071114; DOI=10.1111/j.1349-7006.1994.tb02420.x; PMCID=PMC5919549
Terasaki T., Matsuno Y., Shimosato Y., Yamaguchi K., Ichinose H., Nagatsu T., Kato K.
Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.
Jpn. J. Cancer Res. 85:718-722(1994)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681
Yokoi S., Yasui K., Saito-Ohara F., Koshikawa K., Iizasa T., Fujisawa T., Terasaki T., Horii A., Takahashi T., Hirohashi S., Inazawa J.
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Hum. Cell 37:944-950(2024)

Cross-references
Cell line collections (Providers) RCB; RCB1184
Cell line databases/resources CLO; CLO_0037024
CLO; CLO_0050069
cancercelllines; CVCL_1391
Cell_Model_Passport; SIDM00292
CGH-DB; 99-1
CGH-DB; 9067-4
Cosmic-CLP; 753589
DepMap; ACH-002077
LINCS_LDP; LCL-1873
Biological sample resources BioSample; SAMN03472172
Chemistry resources ChEMBL-Cells; CHEMBL3308239
ChEMBL-Targets; CHEMBL2366132
GDSC; 753589
PharmacoDB; LU165_868_2019
PubChem_Cell_line; CVCL_1391
Encyclopedic resources Wikidata; Q54903204
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670066
Polymorphism and mutation databases Cosmic; 753589
Cosmic; 1212197
Cosmic; 1571740
Cosmic; 1995496
Cosmic; 2125173
IARC_TP53; 21481
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number39