ID KP-N-YS AC CVCL_1342 SY KPNYS; Kyoto Pediatrics-Neuroblastoma-YS DR CLO; CLO_0037080 DR ArrayExpress; E-MTAB-783 DR BioGRID_ORCS_Cell_line; 916 DR cancercelllines; CVCL_1342 DR Cell_Model_Passport; SIDM00157 DR CGH-DB; 82-1 DR CGH-DB; 9083-4 DR ChEMBL-Cells; CHEMBL3308266 DR ChEMBL-Targets; CHEMBL2366065 DR Cosmic; 946363 DR Cosmic-CLP; 946363 DR DepMap; ACH-002261 DR GDSC; 946363 DR GEO; GSM1670008 DR IARC_TP53; 27174 DR LINCS_LDP; LCL-1986 DR PharmacoDB; KPNYS_789_2019 DR PRIDE; PXD030304 DR PubChem_Cell_line; CVCL_1342 DR Wikidata; Q54900406 RX CelloPub=CLPUB00582; RX PubMed=10363161; RX PubMed=11129446; RX PubMed=12702577; RX PubMed=20164919; RX PubMed=23268333; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Homozygous (Cosmic-CLP=946363). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=1.29%; East Asian, North=74.96%; East Asian, South=23.74%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373). CC Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371. ST Source(s): Cosmic-CLP=946363 ST Amelogenin: X,Y ST CSF1PO: 10,11 ST D13S317: 8,12 ST D16S539: 10 ST D5S818: 9,13 ST D7S820: 10,12 ST TH01: 7 ST TPOX: 9,11 ST vWA: 14 DI NCIt; C4827; Adrenal gland neuroblastoma DI ORDO; Orphanet_635; Neuroblastoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 4Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 38 CH CVCL_Y132 ! KP-N-YS1n CH CVCL_Y133 ! KP-N-YS2s // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=10363161; RA Yagi, Masayo RA Sugimoto, Tohru RA Mine, Hiroshi RA Horii, Yoshihiro RA Matsumura, Takafumi RA Sawada, Tadashi RA Abe, Tatsuo RA Sano, Kimihiko RA Goshi, Junko RA Takahashi, Katsuhito RT "Basic calponin expressing human neuroblastoma cell line of KP-N-YS."; RL Hum. Cell 11:231-238(1998). // RX PubMed=23268333; DOI=10.1016/j.canlet.2012.12.011; RA Sugimoto, Tohru RA Gotoh, Takahiro RA Yagyu, Shigeki RA Kuroda, Hiroshi RA Iehara, Tomoko RA Hosoi, Hajime RA Ohta, Sigeru RA Ohira, Miki RA Nakagawara, Akira RT "A MYCN-amplified cell line derived from a long-term event-free RT survivor among our sixteen established neuroblastoma cell lines."; RL Cancer Lett. 331:115-121(2013). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=11129446; DOI=10.1097/00019606-200012000-00007; RA Sugimoto, Tohru RA Mine, Hiroshi RA Horii, Yoshihiro RA Takahashi, Katsuhito RA Nagai, Ryozo RA Morishita, Ryuichi RA Komada, Mihiro RA Asada, Yujiro RA Sawada, Tadashi RT "Neuroblastoma cell lines showing smooth muscle cell phenotypes."; RL Diagn. Mol. Pathol. 9:221-228(2000). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=12702577; RA Saito-Ohara, Fumiko RA Imoto, Issei RA Inoue, Jun RA Hosoi, Hajime RA Nakagawara, Akira RA Sugimoto, Tohru RA Inazawa, Johji RT "PPM1D is a potential target for 17q gain in neuroblastoma."; RL Cancer Res. 63:1876-1883(2003). // RX CelloPub=CLPUB00582; RA Sugimoto, Tohru RA Kuroda, Hiroshi RA Yagyu, Shigeki RA Gotoh, Takahiro RA Osone, Shinya RA Tamura, Shinichi RA Iehara, Tomoko RA Hosoi, Hajime RT "Cellular and molecular characteristics of established neuroblastoma RT cell lines."; RL J. Cancer Res. Therap. Oncol. 7:201.1-201.15(2019). //