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Cellosaurus IGR-1 (CVCL_1303)

[Text version]
Cell line name IGR-1
Synonyms IGR 1; IGR1; Institut Gustave Roussy-1
Accession CVCL_1303
Resource Identification Initiative To cite this cell line use: IGR-1 (RRID:CVCL_1303)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~75-100 hours (DSMZ=ACC-236).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Inguinal lymph node; UBERON=UBERON_0001542.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (PubMed=25056119; Cosmic-CLP; DepMap).
  • Mutation; HGNC; 9801; RAC1; Simple; p.Pro29Ser (c.85C>T); ClinVar=VCV000376362; Zygosity=Heterozygous (PubMed=25056119; Cosmic-CLP; DepMap).
HLA typing Source: CLS=300219
Class I
HLA-AA*02:01:01,03:01:01
HLA-BB*11:01:01,44:02:01
HLA-CC*04:01:01,05:01:01
Class II
HLA-DPDPB1*04:01:01G,04:02:01G
HLA-DQDQA1*01:01:01,03:03:01
DQB1*03:01:01,05:01:01
HLA-DRDRB1*01:01:01,04:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.53
Native American0
East Asian, North2.53
East Asian, South0
South Asian0.58
European, North60.87
European, South35.49
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B5LI (IGR-10)CVCL_RS51 (IGR-1rCDDP2000)CVCL_RS52 (IGR-1rDACARB40)
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; DSMZ; PubMed=25056119; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D2S133820,22
D3S135814,17
D5S81810,11 (CLS; Cosmic-CLP; DSMZ; PubMed=25877200)
10,14 (PubMed=25056119)
D7S82010,11
D8S117910 (CLS)
10,14 (DSMZ; PubMed=25056119; PubMed=25877200)
D13S31713
D16S53911 (PubMed=25056119)
11,13 (CLS; Cosmic-CLP; DSMZ; PubMed=25877200)
D18S5114,16 (DSMZ; PubMed=25877200)
16 (CLS)
D19S43315,16
D21S1132.2
FGA23,24
Penta D10
Penta E7,11
TH017,9.3 (CLS)
9.3 (Cosmic-CLP; DSMZ; PubMed=25056119; PubMed=25877200)
TPOX8
vWA17,18 (CLS; Cosmic-CLP; DSMZ; PubMed=25877200)
18 (PubMed=25056119)

Run an STR similarity search on this cell line
Publications

PubMed=4153924
Janiaud P., Le Calvez J., Aubert C.
Cytoenzymological caracterization of cells from human skin melanoma in culture.
Ann. Dermatol. Syphiligr. (Paris). 100:536-539(1973)

PubMed=954556; DOI=10.1016/0014-2964(76)90033-5
Aubert C., Lagrange C., Rorsman H., Rosengren E.
Catechols in primary and metastatic human malignant melanoma cells in monolayer culture.
Eur. J. Cancer 12:441-445(1976)

PubMed=405430; DOI=10.1111/1523-1747.ep12496554
Foa C., Aubert C.
Cellular localization of tyrosinase in human malignant melanoma cell lines.
J. Invest. Dermatol. 68:369-378(1977)

PubMed=6929009; DOI=10.1093/jnci/64.5.1029
Aubert C., Rouge F., Galindo J.R.
Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.
J. Natl. Cancer Inst. 64:1029-1040(1980)

PubMed=1822769; DOI=10.1097/00008390-199104000-00002
Karg E., Odh G., Rosengren E., Wittbjer A., Rorsman H.
Melanin-related biochemistry of IGR 1 human melanoma cells.
Melanoma Res. 1:5-13(1991)

PubMed=11668190; DOI=10.1177/002215540104901105
Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25056119; DOI=10.1158/0008-5472.CAN-14-1232-T
Watson I.R., Li L.-R., Cabeceiras P.K., Mahdavi M., Gutschner T., Genovese G., Wang G.-C., Fang Z.-N., Tepper J.M., Stemke-Hale K., Tsai K.Y., Davies M.A., Mills G.B., Chin L.
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.
Cancer Res. 74:4845-4852(2014)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 300219
CLS; 300219-SF
DSMZ; ACC-236
Cell line databases/resources CLO; CLO_0006669
CLDB; cl2624
cancercelllines; CVCL_1303
Cell_Model_Passport; SIDM01060
Cosmic-CLP; 907169
DepMap; ACH-000882
DSMZCellDive; ACC-236
LINCS_LDP; LCL-1247
Biological sample resources BioSample; SAMN03472901
BioSample; SAMN10987998
CRISP screens repositories BioGRID_ORCS_Cell_line; 639
Chemistry resources ChEMBL-Cells; CHEMBL3308749
ChEMBL-Targets; CHEMBL1075479
GDSC; 907169
PharmacoDB; IGR1_651_2019
PubChem_Cell_line; CVCL_1303
Encyclopedic resources Wikidata; Q54897358
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887157
GEO; GSM888229
GEO; GSM1669927
Polymorphism and mutation databases Cosmic; 907169
Cosmic; 2230115
IARC_TP53; 21394
LiGeA; CCLE_169
Progenetix; CVCL_1303
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number41