ID   FTC-133
AC   CVCL_1219
SY   FTC133
DR   BTO; BTO:0001889
DR   CLO; CLO_0003402
DR   CLDB; cl1398
DR   CLDB; cl1399
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03471027
DR   BioSample; SAMN10987983
DR   cancercelllines; CVCL_1219
DR   CCRID; 1101HUM-PUMC000687
DR   Cell_Model_Passport; SIDM00213
DR   ChEMBL-Cells; CHEMBL3308732
DR   ChEMBL-Targets; CHEMBL1075445
DR   Cosmic; 906864
DR   Cosmic; 928831
DR   Cosmic; 1239976
DR   Cosmic; 1280044
DR   Cosmic; 1507371
DR   Cosmic; 1533556
DR   Cosmic; 1536124
DR   Cosmic; 1889011
DR   Cosmic; 2054103
DR   Cosmic; 2319848
DR   Cosmic; 2791091
DR   Cosmic-CLP; 906864
DR   DepMap; ACH-000903
DR   ECACC; 94060901
DR   EGA; EGAS00001000978
DR   GDSC; 906864
DR   GEO; GSM827308
DR   GEO; GSM887012
DR   GEO; GSM888081
DR   GEO; GSM1669794
DR   IARC_TP53; 21332
DR   ICLC; HTL97015
DR   LiGeA; CCLE_543
DR   LINCS_LDP; LCL-1677
DR   PharmacoDB; FTC133_368_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1219
DR   PubChem_Cell_line; CVCL_1219
DR   Wikidata; Q54835217
RX   PubMed=1384245;
RX   PubMed=1726925;
RX   PubMed=2247845;
RX   PubMed=14522906;
RX   PubMed=17804723;
RX   PubMed=18713817;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=23162534;
RX   PubMed=23833040;
RX   PubMed=23866977;
RX   PubMed=24196587;
RX   PubMed=25675381;
RX   PubMed=25877200;
RX   PubMed=25930030;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=29066502;
RX   PubMed=30737244;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31395879;
RX   PubMed=34445479;
RX   PubMed=35839778;
CC   Group: Space-flown cell line (cellonaut).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: TCGA-110-CL cell line panel.
CC   Population: Caucasian.
CC   Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
CC   HLA typing: A*03:01,03:01; B*07:02,07:02; C*07:02,07:02; DQA1*01:02,01:02; DQB1*06:01,06:01; DRB1*03:05 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 27310; FLCN; Simple; p.His429Thrfs*39 (c.1285delC); ClinVar=VCV000003364; Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Lys1045fs (c.3135delG); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; 7765; NF1; Simple; p.Cys167Ter (c.501T>A); ClinVar=VCV001048706; Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Arg130Ter (c.388C>T); ClinVar=VCV000007819; Zygosity=Homozygous (PubMed=23162534; PubMed=23833040; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Homozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=14522906; PubMed=23162534; PubMed=30737244).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Mitochondrial genome sequenced.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=1.29%; Native American=1.18%; East Asian, North=4.32%; East Asian, South=0%; South Asian=0%; European, North=56.94%; European, South=36.26% (PubMed=30894373).
CC   Anecdotal: Have been flown in space on Shenzhou-8 and on the ISS to study growth in microgravity (PubMed=23866977; PubMed=24196587; PubMed=25930030).
CC   Misspelling: FTC-113; Cosmic=1889011.
CC   Misspelling: CFT-133; PubMed=1384245; Note=In the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): Cosmic-CLP; ECACC; PubMed=18713817; PubMed=25877200; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 10 (Cosmic-CLP; ECACC; PubMed=25877200)
ST   CSF1PO: 10,11 (PubMed=30737244)
ST   D13S317: 11
ST   D16S539: 11
ST   D18S51: 11,12
ST   D19S433: 12,13
ST   D21S11: 32.2
ST   D2S1338: 20
ST   D3S1358: 15
ST   D5S818: 11,12 (PubMed=30737244)
ST   D5S818: 12 (Cosmic-CLP; ECACC; PubMed=18713817; PubMed=25877200)
ST   D7S820: 9,10 (Cosmic-CLP; ECACC; PubMed=18713817; PubMed=30737244)
ST   D7S820: 10 (PubMed=25877200)
ST   D8S1179: 10
ST   FGA: 21
ST   Penta D: 12
ST   Penta E: 13
ST   TH01: 6.1,9.3 (PubMed=25877200)
ST   TH01: 9.3 (Cosmic-CLP; ECACC; PubMed=30737244)
ST   TPOX: 9
ST   vWA: 15,18
DI   NCIt; C8054; Thyroid gland follicular carcinoma
DI   ORDO; Orphanet_146; Differentiated thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2446 ! FTC-236
OI   CVCL_2447 ! FTC-238
SX   Male
AG   42Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 39
//
RX   PubMed=1384245; DOI=10.1007/BF02067383;
RA   Demeure M.J., Damsky C.H., Elfman F., Goretzki P.E., Wong M.G.,
RA   Clark O.H.;
RT   "Invasion by cultured human follicular thyroid cancer correlates with
RT   increased beta 1 integrins and production of proteases.";
RL   World J. Surg. 16:770-776(1992).
//
RX   PubMed=1726925;
RA   Gerber H., Peter H.-J., Asmis L., Studer H.;
RT   "Thyroid cell lines in research on goitrogenesis.";
RL   Thyroidology 3:115-118(1991).
//
RX   PubMed=2247845;
RA   Demeure M.J., Hughes-Fulford M., Goretzki P.E., Duh Q.-Y., Clark O.H.;
RT   "Actin architecture of cultured human thyroid cancer cells: predictor
RT   of differentiation?";
RL   Surgery 108:986-992(1990).
//
RX   PubMed=14522906;
RA   Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R.,
RA   Vigneri P.;
RT   "p73 tumor-suppressor activity is impaired in human thyroid cancer.";
RL   Cancer Res. 63:5829-5837(2003).
//
RX   PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026;
RA   van Staveren W.C.G., Weiss-Solis D.Y., Delys L., Duprez L., Andry G.,
RA   Franc B., Thomas G., Libert F., Dumont J.E., Detours V., Maenhaut C.;
RT   "Human thyroid tumor cell lines derived from different tumor types
RT   present a common dedifferentiated phenotype.";
RL   Cancer Res. 67:8113-8120(2007).
//
RX   PubMed=18713817; DOI=10.1210/jc.2008-1102;
RA   Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M.,
RA   Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. III, Smallridge R.C.,
RA   Haugen B.R.;
RT   "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer
RT   cell lines reveals cross-contamination resulting in cell line
RT   redundancy and misidentification.";
RL   J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23162534; DOI=10.3389/fendo.2012.00133;
RA   Saiselet M., Floor S., Tarabichi M., Dom G., Hebrant A.,
RA   van Staveren W.C.G., Maenhaut C.;
RT   "Thyroid cancer cell lines: an overview.";
RL   Front. Endocrinol. 3:133.1-133.9(2012).
//
RX   PubMed=23833040; DOI=10.1210/jc.2013-2383;
RA   Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M.,
RA   Ibrahimpasic T., Ghossein R.A., Fagin J.A.;
RT   "Frequent somatic TERT promoter mutations in thyroid cancer: higher
RT   prevalence in advanced forms of the disease.";
RL   J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
//
RX   PubMed=23866977; DOI=10.1016/j.biomaterials.2013.06.054;
RA   Pietsch J., Ma X., Wehland M., Aleshcheva G., Schwarzwalder A.,
RA   Segerer J., Birlem M., Horn A., Bauer J., Infanger M., Grimm D.;
RT   "Spheroid formation of human thyroid cancer cells in an automated
RT   culturing system during the Shenzhou-8 Space mission.";
RL   Biomaterials 34:7694-7705(2013).
//
RX   PubMed=24196587; DOI=10.1096/fj.13-243287;
RA   Ma X., Pietsch J., Wehland M., Schulz H., Saar K., Hubner N.,
RA   Bauer J., Braun M., Schwarzwalder A., Segerer J., Birlem M., Horn A.,
RA   Hemmersbach R., Wasser K., Grosse J., Infanger M., Grimm D.;
RT   "Differential gene expression profile and altered cytokine secretion
RT   of thyroid cancer cells in space.";
RL   FASEB J. 28:813-835(2014).
//
RX   PubMed=25675381; DOI=10.1210/jc.2014-2764;
RA   von Roemeling C.A., Marlow L.A., Pinkerton A.B., Crist A., Miller J.,
RA   Tun H.W., Smallridge R.C., Copland J.A. III;
RT   "Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals
RT   stearoyl CoA desaturase 1 as a novel therapeutic target.";
RL   J. Clin. Endocrinol. Metab. 100:E697-E709(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25930030; DOI=10.1002/pmic.201500067;
RA   Riwaldt S., Pietsch J., Sickmann A., Bauer J., Braun M., Segerer J.,
RA   Schwarzwalder A., Aleshcheva G., Corydon T.J., Infanger M., Grimm D.;
RT   "Identification of proteins involved in inhibition of spheroid
RT   formation under microgravity.";
RL   Proteomics 15:2945-2952(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29066502; DOI=10.1530/ERC-17-0288;
RA   Corver W.E., Demmers J., Oosting J., Sahraeian S., Boot A., Ruano D.,
RA   van Wezel T., Morreau H.;
RT   "ROS-induced near-homozygous genomes in thyroid cancer.";
RL   Endocr. Relat. Cancer 25:83-97(2018).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31395879; DOI=10.1038/s41467-019-11415-2;
RA   Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M.,
RA   van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.;
RT   "Comprehensive transcriptomic analysis of cell lines as models of
RT   primary tumors across 22 tumor types.";
RL   Nat. Commun. 10:3574.1-3574.11(2019).
//
RX   PubMed=34445479; DOI=10.3390/ijms22168777;
RA   Melnik D., Kruger M., Schulz H., Kopp S., Wehland M., Bauer J.,
RA   Baselet B., Vermeesen R., Baatout S., Corydon T.J., Infanger M.,
RA   Grimm D.;
RT   "The CellBox-2 mission to the International Space Station: thyroid
RT   cancer cells in space.";
RL   Int. J. Mol. Sci. 22:8777.1-8777.21(2021).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//