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Cellosaurus DMS 79 (CVCL_1178)

[Text version]
Cell line name DMS 79
Synonyms DMS-79; DMS79; Darmouth Medical School 79
Accession CVCL_1178
Resource Identification Initiative To cite this cell line use: DMS 79 (RRID:CVCL_1178)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 3.9 days (PubMed=6266631); 5.8 days (PubMed=2986244); ~4 days (CLS=300164).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: DMS76; Note=In text of PubMed=20439192.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 9683; PTPRU; Simple; p.Glu442Ter (c.1324G>T); Zygosity=Heterozygous (Cosmic-CLP=753551; DepMap=ACH-000703).
  • Mutation; HGNC; 9884; RB1; Simple; p.Gly801Ter (c.2401G>T); Zygosity=Homozygous (Cosmic-CLP=753551; DepMap=ACH-000703).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Glufs*65 (c.837delG) (p.G279fs); Zygosity=Unspecified (DepMap=ACH-000703).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,02:01
HLA-BB*08:01,35:01
HLA-CC*04:01,07:01
Class II
HLA-DQDQB1*03:09,05:03
HLA-DRDRB1*11:30,11:30

Source: PubMed=26589293
Class I
HLA-AA*01:01,02:01
HLA-BB*08:01,35:01
HLA-CC*04:01,07:01
Class II
HLA-DQDQB1*03:09,05:03
HLA-DRDRB1*11:30,11:30
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.52
Native American0
East Asian, North0.95
East Asian, South0
South Asian1.45
European, North66.84
European, South30.24
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2049; CLS=300164; Cosmic-CLP=753551; ECACC=95062824; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,25
D3S135818
D5S81810
D7S8209,11
D8S117912,14
D13S31711
D16S53912
D18S5114,17
D19S43313.2,15
D21S1130
FGA21
Penta D11,13
Penta E7
TH018
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=DMS%2079
https://tcpaportal.org/mclp/
https://www.atcc.org/en/support/technical-support/faqs/normal-growth-of-item-crl-2049
Publications

PubMed=6266631; DOI=10.1002/1097-0142(19800301)45:5<906::AID-CNCR2820450513>3.0.CO;2-H
Pettengill O.S., Sorenson G.D., Wurster-Hill D.H., Curphey T.J., Noll W.W., Cate C.C., Maurer L.H.
Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung.
Cancer 45:906-918(1980)

PubMed=2986244; DOI=10.1007/978-3-642-82372-5_5
Vindelov L.L., Hansen H.H., Spang-Thomsen M.
Growth characteristics and heterogeneity of small cell carcinoma of the lung.
Recent Results Cancer Res. 97:47-54(1985)

PubMed=8383976; DOI=10.1677/jme.0.0100025
Farrell W.E., Stewart M.F., Clark A.J.L., Crosby S.R., Davis J.R.E., White A.
Glucocorticoid inhibition of ACTH peptides: small cell lung cancer cell lines are more resistant than pituitary corticotroph adenoma cells.
J. Mol. Endocrinol. 10:25-32(1993)

PubMed=9744504; DOI=10.1038/bjc.1998.553; PMCID=PMC2063065
Damstrup L., Voldborg B.G.R., Spang-Thomsen M., Brunner N., Poulsen H.S.
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.
Br. J. Cancer 78:631-640(1998)

PubMed=12712436; DOI=10.1002/ijc.11106
Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Int. J. Cancer 105:472-479(2003)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S., Nakagawa K., Nomura H., Ishikawa Y.
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367
Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K., Sauter G., Lesniewski R., Semizarov D.
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Mol. Cancer Res. 5:331-339(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922
Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer Discov. 2:798-811(2012)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2049
CLS; 300164
ECACC; 95062824
ICLC; HTL98009
Cell line databases/resources CLO; CLO_0002800
CLO; CLO_0002802
CLDB; cl1082
CLDB; cl4907
cancercelllines; CVCL_1178
Cell_Model_Passport; SIDM00524
Cosmic-CLP; 753551
DepMap; ACH-000703
IGRhCellID; DMS79
LINCS_LDP; LCL-1832
Biological sample resources BioSample; SAMN03473247
BioSample; SAMN10988337
Chemistry resources ChEMBL-Cells; CHEMBL3307581
ChEMBL-Targets; CHEMBL614286
GDSC; 753551
PharmacoDB; DMS79_301_2019
PubChem_Cell_line; CVCL_1178
Encyclopedic resources Wikidata; Q54831312
Experimental variables resources EFO; EFO_0002166
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM17308
GEO; GSM169445
GEO; GSM886985
GEO; GSM888054
GEO; GSM1669738
Polymorphism and mutation databases Cosmic; 753551
Cosmic; 1609526
Cosmic; 2648007
IARC_TP53; 21309
LiGeA; CCLE_666
Progenetix; CVCL_1178
Proteomic databases PRIDE; PXD011896
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number41