ID   COLO 829
AC   CVCL_1137
SY   COLO-829; Colo-829; Colo 829; COLO #829; COLO829; Colo829; Colorado 829
DR   CLO; CLO_0002563
DR   CLO; CLO_0037123
DR   EFO; EFO_0002140
DR   CLDB; cl856
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1974
DR   BioSample; SAMN03470888
DR   BioSample; SAMN10988208
DR   cancercelllines; CVCL_1137
DR   Cell_Model_Passport; SIDM00909
DR   ChEMBL-Cells; CHEMBL3308286
DR   ChEMBL-Targets; CHEMBL2366275
DR   Cosmic; 687448
DR   Cosmic; 965553
DR   Cosmic; 1459644
DR   Cosmic; 1477404
DR   Cosmic; 1995376
DR   Cosmic; 2159430
DR   Cosmic-CLP; 687448
DR   dbGAP; phs001839.v1.p1
DR   DepMap; ACH-000644
DR   ECACC; 93052611
DR   EGA; EGAS00000000052
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   ENCODE; ENCBS172AAA
DR   GDSC; 687448
DR   GEO; GSE151409
DR   GEO; GSM206465
DR   GEO; GSM274683
DR   GEO; GSM886953
DR   GEO; GSM888021
DR   GEO; GSM1008571
DR   GEO; GSM1178047
DR   GEO; GSM1178048
DR   GEO; GSM1669695
DR   IARC_TP53; 21246
DR   IGRhCellID; COLO829
DR   IZSLER; BS TCL 198
DR   LiGeA; CCLE_650
DR   LINCS_LDP; LCL-1269
DR   PharmacoDB; COLO829_238_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1137
DR   PubChem_Cell_line; CVCL_1137
DR   Wikidata; Q54814157
RX   PubMed=7780963;
RX   PubMed=12068308;
RX   PubMed=14762065;
RX   PubMed=18698037;
RX   PubMed=20016485;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=23285177;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27094764;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=32587328;
RX   PubMed=35839778;
WW   https://tcpaportal.org/mclp/
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/Colo829_Crawford_protocol.pdf
WW   https://www.cellosaurus.org/pawefish/OtherCellLineDescriptions/COLO829.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: ENCODE project common cell types; tier 3.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Characteristics: Single cell sequencing has shown that it is composed of four major sub-clones (PubMed=32587328).
CC   HLA typing: A*01:01,01:01; B*08:01,40:02; C*03:04,07:06 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=12068308; PubMed=27094764; ATCC; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Ala68Glyfs*51 (c.203_204delCG); Zygosity=Homozygous (PubMed=27094764; ATCC).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.493_634del142; Zygosity=Homozygous (ATCC).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.228_229CC>TT (-124/-125CC>TT); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Genome sequenced.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Single cell genome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.12%; Native American=0%; East Asian, North=2.63%; East Asian, South=0%; South Asian=0%; European, North=71.18%; European, South=26.07% (PubMed=30894373).
CC   Discontinued: ECACC; 93052611; probable.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
ST   Source(s): ATCC; Cosmic-CLP; DepMap; IZSLER; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11,12
ST   D16S539: 13
ST   D18S51: 15
ST   D21S11: 27,29
ST   D3S1358: 16,18
ST   D5S818: 11
ST   D7S820: 8,10
ST   D8S1179: 13,14
ST   FGA: 21,25
ST   Penta D: 9,14
ST   Penta E: 7,12
ST   TH01: 10
ST   TPOX: 8,11
ST   vWA: 17,19
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1999 ! COLO 829BL
OI   CVCL_L503 ! COLO 831
OI   CVCL_2000 ! COLO 832
OI   CVCL_L504 ! COLO 833
OI   CVCL_L505 ! COLO 834
OI   CVCL_L506 ! COLO 835
OI   CVCL_L507 ! COLO 838
OI   CVCL_2001 ! COLO 839
OI   CVCL_L508 ! COLO 845
OI   CVCL_L509 ! COLO 848
OI   CVCL_2002 ! COLO 849
OI   CVCL_2003 ! COLO 853
OI   CVCL_2004 ! COLO 857
OI   CVCL_2005 ! COLO 858
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 40
//
RX   PubMed=7780963;
RA   Easty D.J., Guthrie B.A., Maung K., Farr C.J., Lindberg R.A.,
RA   Toso R.J., Herlyn M., Bennett D.C.;
RT   "Protein B61 as a new growth factor: expression of B61 and
RT   up-regulation of its receptor epithelial cell kinase during melanoma
RT   progression.";
RL   Cancer Res. 55:2528-2532(1995).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S.,
RA   Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N.,
RA   Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J.,
RA   Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S.,
RA   Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S.,
RA   Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J.,
RA   Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A.,
RA   Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T.,
RA   Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R.,
RA   Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.;
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=14762065; DOI=10.1101/gr.2012304;
RA   Bignell G.R., Huang J., Greshock J., Watt S., Butler A.P., West S.,
RA   Grigorova M., Jones K.W., Wei W., Stratton M.R., Futreal P.A.,
RA   Weber B., Shapero M.H., Wooster R.;
RT   "High-resolution analysis of DNA copy number using oligonucleotide
RT   microarrays.";
RL   Genome Res. 14:287-295(2004).
//
RX   PubMed=18698037; DOI=10.1158/1078-0432.CCR-08-0186;
RA   Reschke M., Mihic-Probst D., van der Horst E.H., Knyazev P.,
RA   Wild P.J., Hutterer M., Meyer S., Dummer R., Moch H., Ullrich A.;
RT   "HER3 is a determinant for poor prognosis in melanoma.";
RL   Clin. Cancer Res. 14:5188-5197(2008).
//
RX   PubMed=20016485; DOI=10.1038/nature08658;
RA   Pleasance E.D., Cheetham R.K., Stephens P.J., McBride D.J.,
RA   Humphray S.J., Greenman C.D., Varela I., Lin M.-L., Ordonez G.R.,
RA   Bignell G.R., Ye K., Alipaz J., Bauer M.J., Beare D., Butler A.P.,
RA   Carter R.J., Chen L., Cox A.J., Edkins S., Kokko-Gonzales P.I.,
RA   Gormley N.A., Grocock R.J., Haudenschild C.D., Hims M.M., James T.,
RA   Jia M.-M., Kingsbury Z., Leroy C., Marshall J., Menzies A., Mudie L.J.,
RA   Ning Z.-M., Royce T., Schulz-Trieglaff O.B., Spiridou A., Stebbings L.A.,
RA   Szajkowski L., Teague J.W., Williamson D., Chin L., Ross M.T.,
RA   Campbell P.J., Bentley D.R., Futreal P.A., Stratton M.R.;
RT   "A comprehensive catalogue of somatic mutations from a human cancer
RT   genome.";
RL   Nature 463:191-196(2010).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23285177; DOI=10.1371/journal.pone.0052760;
RA   Schayowitz A.B., Bertenshaw G.P., Jeffries E., Schatz T., Cotton J.,
RA   Villanueva J., Herlyn M., Krepler C., Vultur A., Xu W., Yu G.H.,
RA   Schuchter L.M., Clark D.P.;
RT   "Functional profiling of live melanoma samples using a novel automated
RT   platform.";
RL   PLoS ONE 7:E52760-E52760(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27094764; DOI=10.1038/srep24607;
RA   Craig D.W., Nasser S., Corbett R., Chan S.K., Murray L., Legendre C.,
RA   Tembe W., Adkins J., Kim N., Wong S.-M., Baker A., Enriquez D., Pond S.,
RA   Pleasance E.D., Mungall A.J., Moore R.A., McDaniel T., Ma Y.,
RA   Jones S.J.M., Marra M.A., Carpten J.D., Liang W.S.;
RT   "A somatic reference standard for cancer genome sequencing.";
RL   Sci. Rep. 6:24607-24607(2016).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023;
RA   Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III,
RA   Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K.,
RA   Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
RA   Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A.,
RA   Sellers W.R., Gygi S.P.;
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=32587328; DOI=10.1038/s42003-020-1044-8;
RA   Velazquez-Villarreal E.I., Maheshwari S., Sorenson J., Fiddes I.T.,
RA   Kumar V., Yin Y.-F., Webb M.G., Catalanotti C., Grigorova M.,
RA   Edwards P.A.W., Carpten J.D., Craig D.W.;
RT   "Single-cell sequencing of genomic DNA resolves sub-clonal
RT   heterogeneity in a melanoma cell line.";
RL   Commun. Biol. 3:318.1-318.8(2020).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//